Targeting the PI3K/Akt/mTOR pathway for breast cancer therapy.
Targeting the PI3K/Akt/mTOR pathway for breast cancer therapy.
复制标题
DOI：
10.1007/s10911-012-9264-2
复制
发表时间：
2012-12
影响因子：
2.5
通讯作者：
Park BH
中科院分区：
文献类型：
--
作者：
Cidado J;Park BH
Recent advances in genetics and genomics have revealed new pathways that are aberrantly activated in many breast cancers. Chief among these genetic changes are somatic mutations and/or gains and losses of key genes within the phosphoinositide 3-kinase (PI3K) pathway. Since breast cancer cell growth and progression is often dependent upon activation of the PI3K pathway, there has been intense research interest in finding therapeutic agents that can selectively inhibit one or more constituents of this signaling cascade. Here we review key molecules involved with aberrant PI3K pathway activation in breast cancers and current efforts to target these components for therapeutic gain.
登录
查看更多内容
影响因子：
3.6
作者：
Bachman, KE;Argani, P;Park, BH
通讯作者：
Park, BH
影响因子：
4.8
作者：
Castro, AF;Rebhun, JF;Quilliam, LA
通讯作者：
Quilliam, LA
影响因子：
45.3
作者：
Amir, Eitan;Miller, Naomi;Clemons, Mark
通讯作者：
Clemons, Mark
影响因子：
3.2
作者：
Carol, Hernan;Morton, Christopher L.;Gorlick, Richard;Kolb, E. Anders;Keir, Stephen T.;Reynolds, C. Patrick;Kang, Min H.;Maris, John M.;Billups, Catherine;Smith, Malcolm A.;Houghton, Peter J.;Lock, Richard B.
通讯作者：
Lock, Richard B.
DOI：
10.1073/pnas.1018001108
发表时间：
2012-02-21
影响因子：
11.1
作者：
Chakrabarty, Anindita;Sanchez, Violeta;Arteaga, Carlos L.
通讯作者：
Arteaga, Carlos L.