T lymphocyte subsets and viral infections in sardinian parenteral drug abusers: Relationship to HIV infection
T lymphocyte subsets and viral infections in sardinian parenteral drug abusers: Relationship to HIV infection
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撒丁岛肠外药物滥用者的 T 淋巴细胞亚群和病毒感染：与 HIV 感染的关系
DOI：
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发表时间：
1989
影响因子：
12.7
通讯作者：
A. Balestrieri
中科院分区：
文献类型：
--
作者：
P. Farci;D. Novick;M. Lai;G. Orgiana;D. De Gioannis;A. Coiana;A. Strazzera;F. Marongiu;A. Balestrieri
为探讨人类免疫缺陷病毒（HIV）感染或滥用麻醉药品或其他病毒感染是否可能导致胃肠外药物滥用者的免疫异常，从1985年至1986年收集了168例连续个体患者的血清。对血清进行HIV抗体（抗HIV）检测，并对83例血清阳性和53例血清阴性的胃肠外药物滥用者的临床、免疫学和血清学特征进行比较。抗HIV抗体的存在与辅助性T淋巴细胞数量减少（P < 0.001）、辅助性/抑制性T淋巴细胞比例降低（P < 0.001）和全身性淋巴结病（P < 0.001）显著相关。在83例血清阳性患者中，63例（76%）有全身淋巴结病，16例（18%）有艾滋病相关综合征。没有病人得艾滋病。与淋巴结病综合征（LAS）患者相比，有艾滋病相关综合征的肠外药物滥用者的T辅助细胞数量（P < 0.01）和T辅助细胞/抑制细胞比率（P < 0.01）显著降低，表明HIV感染的肠外药物滥用者发生了进行性免疫缺陷。抗HIV抗体阳性者中有75%和抗HIV抗体阴性者中有45%（P < 0.01）存在抗巨细胞病毒IgG抗体，但抗HIV抗体与其他病毒标志物之间无显著相关性。我们的数据证实HIV感染是导致静脉吸毒者辅助性T细胞减少和辅助性/抑制性T细胞比例逆转的主要原因。
To investigate whether the human immunodeficiency virus (HIV) infection or the abuse of narcotic drugs or other viral infections may be responsible for immunologic abnormalities in parenteral drug abusers, sera from 168 consecutive individual patients were collected from 1985 to 1986. The sera were tested for antibody to HIV (anti‐HIV), and the clinical, immunologic, and serologic characteristics of 83 seropositive and 53 seronegative parenteral drug abusers were compared. The presence of anti‐HIV was significantly associated with a decreased number of T helper lymphocytes (P < 0.001), a reduced T helper/suppressor ratio (P < 0.001), and generalized lymphadenopathy (P < 0.001). Of the 83 seropositive patients, 63 (76%) had generalized lymphadenopathy and 16 (18%) had AIDS‐related complex. No patient had AIDS. Parenteral drug abusers with AIDS‐related complex had significant reductions in the number of T helper cells (P < 0.01) and the T helper/suppressor ratio (P < 0.01) compared with patients with lymphadenopathy syndrome (LAS), suggesting that parenteral drug abusers with HIV infection develop a progressive immunodeficiency. IgG antibody to cytomegalovirus was found in 75% of anti‐HIV‐positive and 45% of anti‐HIV‐negative parenteral drug abusers (P < 0.01), but significant associations between anti‐HIV and markers for other viruses were not found. Our data confirm that HIV infection is the major cause of low T helper cells and reversed T helper/suppressor ratio in parenteral drug abusers.
撒丁岛肠外药物滥用者中人类免疫缺陷病毒感染的介绍：一项血清流行病学研究。
影响因子：
5
作者：
Farci,P;Novick,DM;Lai,ME;Orgiana,G;Strazzera,A;Beatrice,ST;DesJarlais,DC;Balestrieri,A
通讯作者：
Balestrieri,A
人类免疫缺陷病毒感染后免疫异常的非随机发展：对该疾病免疫学分类的影响。
DOI：
10.1073/pnas.84.15.5404
发表时间：
1987
影响因子：
11.1
作者：
Zolla-Pazner,S;DesJarlais,DC;Friedman,SR;Spira,TJ;Marmor,M;Holzman,R;Mildvan,D;Yancovitz,S;Mathur-Wagh,U;Garber,J
通讯作者：
Garber,J
静脉吸毒者中的艾滋病毒感染：流行病学和降低风险。
DOI：
--
发表时间：
1987
期刊：
AIDS (London, England)
影响因子：
--
作者：
DesJarlais,DC;Friedman,SR
通讯作者：
Friedman,SR