Diffusion-weighted imaging and diffusion kurtosis imaging for early evaluation of the response to docetaxel in rat epithelial ovarian cancer
Diffusion-weighted imaging and diffusion kurtosis imaging for early evaluation of the response to docetaxel in rat epithelial ovarian cancer
复制标题
扩散加权成像和扩散峰度成像用于早期评估大鼠上皮性卵巢癌多西他赛的反应
DOI：
10.1186/s12967-018-1714-1
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发表时间：
2018-12
影响因子：
7.4
通讯作者：
Tian‐kui Qiao
中科院分区：
文献类型：
--
作者：
Su-juan Yuan;Jin‐Wei Qiang;Tian‐kui Qiao
目的探讨弥散加权磁成像（DWI）和弥散峰度磁成像（DKI）在早期检测卵巢上皮癌（EOC）对多西他赛（DTX）化疗反应中的应用价值。在第0天用DTX治疗患有EOC的大鼠（治疗组）或不治疗（对照组）。分别于治疗后第0、3、7、14、21天行DWI和DKI检查。在第21天，根据肿瘤的大小变化将肿瘤分为敏感组和不敏感组。确定DWI和DKI参数的早期缓解临界值。重复实验，根据最初获得的临界值将治疗组分为敏感组和不敏感组。结果在敏感组、不敏感组和对照组中，DWI和DKI参数（ADC、D和K）的Δ%从第3天开始，肿瘤大小从第14天开始，差异均有统计学意义（P <0.05）。在第7天早期，K的Δ%的AUC为1，灵敏度和特异性值分别为100%和100%，以K降低19.03%的临界值检测对DTX的反应。从第7天开始，敏感组Ki-67和CA 125的Δ%差异有统计学意义。对照组和敏感组与不敏感组从第14天开始。从第14天开始，敏感组Bcl-2的Δ%、凋亡和肿瘤坏死均有显著性差异。对照组或不敏感组。ADC和D的Δ%值与肿瘤大小、Ki-67、CA 125和Bcl-2的Δ%值呈负相关，与细胞凋亡和肿瘤坏死的Δ%值呈正相关。K值的Δ%与肿瘤大小、Ki-67、CA 125和Bcl-2的Δ%值呈正相关，与凋亡和坏死的Δ%值呈负相关。结论DWI和DKI参数，尤其是K值，在肿瘤大小的成像中，对早期检测诱导的大鼠EOC对DTX化疗的反应具有上级优势。
BackgroundTo investigate diffusion-weighted magnetic imaging (DWI) and diffusion kurtosis magnetic imaging (DKI) for the early detection of the response to docetaxel (DTX) chemotherapy in rat epithelial ovarian cancer (EOC).Methods7,12-Dimethylbenz[A]anthracene was applied to induce orthotopic EOC in Sprague–Dawley rats. Rats with EOC were treated with DTX on day 0 (treatment group) or were left untreated (control group). DWI and DKI were performed on days 0, 3, 7, 14 and 21 after treatment. On day 21, the tumors were categorized into the sensitive and insensitive groups according to the size change. The cutoff values of the DWI and DKI parameters for the early response were determined. The experiment was repeated, and the treatment group was divided into the sensitive and insensitive groups according to the initially obtained cutoff values. The DWI and DKI parameters were correlated with tumor size, proliferation, apoptosis and tumor necrosis.ResultsIn the sensitivevs.insensitive or control group, significant differences were found in the Δ% of the DWI and DKI parameters (ADC, D and K) from day 3 and in tumor size from day 14. Early on day 7, the Δ% of K had an AUC of 1 and sensitivity and specificity values of 100% and 100%, respectively, to detect the response to DTX using a cutoff value of 19.03% reduction in K. From day 7, significant differences were found in the Δ% of Ki-67 and CA125 in the sensitivevs. control group and from day 14 in the sensitive vs. insensitive group. From day 14, there were significant differences in the Δ% of Bcl-2, apoptosis and tumor necrosis in the sensitivevs. control or insensitive group. The Δ% values of ADC and D were negatively correlated with the Δ% values of tumor size, Ki-67, CA125 and Bcl-2 and were positively correlated with the Δ% values of apoptosis and tumor necrosis. The Δ% of K was positively correlated with the Δ% values of tumor size, Ki-67, CA125 and Bcl-2 and was negatively correlated with the Δ% values of apoptosis and tumor necrosis.ConclusionsDWI and DKI parameters, especially K, are superior for imaging tumor size for the early detection of the response to DTX chemotherapy in induced rat EOC.
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影响因子：
--
作者：
Morgado M;Sutton MN;Simmons M;Warren CR;Lu Z;Constantinou PE;Liu J;Francis LL;Conlan RS;Bast RC Jr;Carson DD
通讯作者：
Carson DD
影响因子：
6.2
作者：
Bast, Robert C., Jr.
通讯作者：
Bast, Robert C., Jr.
影响因子：
8.4
作者：
Eisenhauer, E. A.;Therasse, P.;Verweij, J.
通讯作者：
Verweij, J.
新诊断的胶质母细胞瘤对放化疗的单指数、扩散峰度和拉伸指数扩散 MR 成像反应。
影响因子：
3.9
作者：
Chakhoyan A;Woodworth DC;Harris RJ;Lai A;Nghiemphu PL;Liau LM;Pope WB;Cloughesy TF;Ellingson BM
通讯作者：
Ellingson BM
DCE-MRI评估诱导性大鼠上皮性卵巢癌组织病理学和分子生物学特征的价值
影响因子：
4
作者：
Yuan SJ;Qiao TK;Qiang JW;Cai SQ;Li RK
通讯作者：
Li RK