Triangulating evidence for the causal impact of single-dose zinc supplement on glycemic control for type-2 diabetes
Triangulating evidence for the causal impact of single-dose zinc supplement on glycemic control for type-2 diabetes
复制标题
单剂量锌补充剂对 2 型糖尿病血糖控制的因果影响的三角测量证据
DOI：
10.1101/2021.12.17.21267964
复制
发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Wang Z
中科院分区：
文献类型：
--
作者：
Wang Z
虽然先前的研究表明锌对2型糖尿病有保护作用，但单一的因果关系尚不确定。目的我们通过系统回顾随机对照试验和两样本孟德尔随机化(MR)，研究锌作为单一干预措施对2型糖尿病患者血糖控制的因果效应。方法确定四种结果：空腹血糖/空腹血糖、糖化血红蛋白(HbA1c)、胰岛素抵抗的稳态模型评估(HOMA-IR)和血清胰岛素/空腹胰岛素水平。在系统评价中，检索了截至2021年6月的四个数据库。结果通过随机效应荟萃分析进行综合。从MR-BASE中选择与锌补充剂密切相关且独立的单核苷酸多态(SNPs)，用逆方差加权(IVW)系数进行两样本MR。与对照组相比，补锌后空腹血糖(平均差值：-26.52，95%CI：-35.13，-17.91)、糖化血红蛋白(MD：-0.52，95%CI：-0.90，-0.13)和HOMA-IR(MD：-1.65，95%CI：-2.62，-0.68)显著降低。在两个样本MR中，补锌加2个SNPs与较低的空腹血糖相关(IVW系数：-2.04，95%CI：-3.26，-0.83)，但不是特定的2型糖尿病。结论尽管这项研究受到少数试验(综述)和SNPs(两样本MR)的限制，但我们证明单一补锌在一定程度上改善了有因果证据的2型糖尿病患者的血糖控制。
BackgroundAlthough previous studies suggested the protective effect of zinc for type-2 diabetes, the unitary causal effect remains inconclusive.ObjectiveWe investigated the causal effect of zinc as a single intervention on glycemic control in type-2 diabetes patients, using a systematic review of RCTs and two-sample Mendelian randomization (MR).MethodsFour outcomes were identified: fasting blood glucose/fasting glucose, hemoglobin A1c (HbA1c), homeostasis model assessment of insulin resistance (HOMA-IR), and serum insulin/fasting insulin level. In the systematic review, four databases were searched up to June 2021. Results were synthesized through the random-effects meta-analysis. Single nucleotide polymorphisms (SNPs) that are independent and are strongly related to zinc supplements were selected from MR-base to perform the two-sample MR with inverse-variance weighted (IVW) coefficient.ResultsIn the systematic review, 14 trials were included. The zinc supplement led to a significant reduction in the post-trial mean of fasting blood glucose (mean difference (MD): - 26.52, 95%CI: -35.13, -17.91), HbA1C (MD: -0.52, 95%CI: -0.90, -0.13), and HOMA-IR (MD: -1.65, 95%CI: -2.62, -0.68), compared to the control group. In the two-sample MR, zinc supplement with 2 SNPs associated with lower fasting glucose (IVW coefficient: -2.04, 95%CI: -3.26, -0.83), but not specified type-2 diabetes.ConclusionAlthough the study was limited by the few trials (review) and SNPs (two-sample MR), we demonstrated that the single zinc supplementary improved glycemic control among type-2 diabetes patients with causal evidence to a certain extent.
登录
查看更多内容
DOI：
10.1348/000711006x126600
发表时间：
2008-05-01
影响因子：
2.6
作者：
Gwet, Kilem Li
通讯作者：
Gwet, Kilem Li
血浆高级氧化蛋白产物增加是无蛋白尿的 2 型糖尿病患者内皮功能障碍的早期标志
影响因子：
4.5
作者：
M. Liang;Jun Wang;Chao Xie;Yan Yang;Jian;Yao;F. Hou
通讯作者：
F. Hou
DOI：
--
发表时间：
2008
期刊：
--
影响因子：
--
作者：
G. Smith;S. Ebrahim
通讯作者：
G. Smith;S. Ebrahim
影响因子：
--
作者：
Lee SR
通讯作者：
Lee SR
影响因子：
4.2
作者：
Powell, SR
通讯作者：
Powell, SR