Sex-based differences in the activation of peripheral blood monocytes in early Parkinson disease.
Sex-based differences in the activation of peripheral blood monocytes in early Parkinson disease.
复制标题
DOI：
10.1038/s41531-021-00180-z
复制
发表时间：
2021-04-13
期刊：
影响因子：
--
通讯作者：
Standaert DG
中科院分区：
文献类型：
--
作者：
Carlisle SM;Qin H;Hendrickson RC;Muwanguzi JE;Lefkowitz EJ;Kennedy RE;Yan Z;Yacoubian TA;Benveniste EN;West AB;Harms AS;Standaert DG
越来越多的证据支持大脑和全身炎症在帕金森病（PD）病因学中的作用。我们使用基因表达谱检测18例早期未经治疗的PD患者和16例健康对照（HC）受试者外周血单核细胞的活化状态。通过阴性选择分离单核细胞，并通过RNA-seq和基因集富集分析研究基因表达。采用了一个计算模型，纳入病例/对照状态，性别，病例/对照状态和性别之间的相互作用。我们发现性别对单核细胞基因表达有显著影响。在PD女性中存在单核细胞的炎症激活，并伴有与干扰素γ刺激相关的基因集富集。在男性中，激活模式更加异质。这些数据指出了全身单核细胞活化在PD中的重要性，以及研究性别对疾病病理生理学的差异影响的重要性。
Increasing evidence supports the role of brain and systemic inflammation in the etiology of Parkinson disease (PD). We used gene expression profiling to examine the activation state of peripheral blood monocytes in 18 patients with early, untreated PD and 16 healthy control (HC) subjects. Monocytes were isolated by negative selection, and gene expression studied by RNA-seq and gene set enrichment analysis. A computational model that incorporated case/control status, sex, and the interaction between case/control status and sex was utilized. We found that there was a striking effect of sex on monocyte gene expression. There was inflammatory activation of monocytes in females with PD, with enrichment of gene sets associated with interferon gamma stimulation. In males, the activation patterns were more heterogeneous. These data point to the importance of systemic monocyte activation in PD, and the importance of studies which examine the differential effects of sex on pathophysiology of the disease.
登录
查看更多内容
影响因子：
6.1
作者：
Cantuti-Castelvetri, Ippolita;Keller-McGandy, Christine;Standaert, David G.
通讯作者：
Standaert, David G.
影响因子：
15.9
作者：
Brochard, Vanessa;Combadiere, Behazine;Hunot, Stephane
通讯作者：
Hunot, Stephane
影响因子：
3.7
作者：
Gardai SJ;Mao W;Schüle B;Babcock M;Schoebel S;Lorenzana C;Alexander J;Kim S;Glick H;Hilton K;Fitzgerald JK;Buttini M;Chiou SS;McConlogue L;Anderson JP;Schenk DB;Bard F;Langston JW;Yednock T;Johnston JA
通讯作者：
Johnston JA
影响因子：
8.6
作者：
Funk, Natalja;Wieghofer, Peter;Biskup, Saskia
通讯作者：
Biskup, Saskia
DOI：
10.4049/jimmunol.1701592
发表时间：
2018-07-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Gibson SA;Yang W;Yan Z;Qin H;Benveniste EN
通讯作者：
Benveniste EN