Direct measurement of proximal isovelocity surface area by real-time three-dimensional color Doppler for quantitation of aortic regurgitant volume: an in vitro validation.
Direct measurement of proximal isovelocity surface area by real-time three-dimensional color Doppler for quantitation of aortic regurgitant volume: an in vitro validation.
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DOI：
10.1016/j.echo.2008.11.031
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发表时间：
2009-03
影响因子：
6.5
通讯作者：
Zoghbi, William A.
中科院分区：
文献类型：
--
作者：
Pirat, Bahar;Little, Stephen H.;Igo, Stephen R.;McCulloch, Marti;Nose, Yukihiko;Hartley, Craig J.;Zoghbi, William A.
近端等流速表面积（比萨）方法可用于定量主动脉瓣返流（AR）。我们假设实时三维（3D）彩色多普勒提供的比萨实际测量结果比二维（2D）彩色多普勒比萨估计的结果更准确。我们开发了一个脉动流模型AR与成像室，其中可互换的节流孔与定义的形状和面积被纳入。使用超声波流量计计算参考稀释剂体积。以72次/min的速率对5个不同形状的孔进行了总共29种不同的流动条件的测试。计算2D比萨为2π r2，并从3D比萨的8个等距径向平面测量3D比萨。反褶积体积的计算公式为：比萨×混叠速度× AR/峰值AR的时间速度积分。通过流量计测量的返流剂体积范围为12.6 - 30.6 mL/次（平均21.4 ± 5.5 mL/次）。通过2D比萨估计的回流体积与通过流量计测量的体积良好相关（r = 0.69）;然而，观察到显著低估（y = 0.5x + 0.6）。对于3D PISA衍生的抑制剂体积，与流量计体积的相关性更强（r = 0.83）;观察到抑制剂体积的低估显著更少，回归线接近同一性（y = 0.9x + 3.9）。直接测量比萨是可行的，没有几何假设，使用实时三维彩色多普勒。用该方法计算主动脉瓣血流容积比传统的半球比萨假设的二维方法更准确。
The proximal isovelocity surface area (PISA) method is useful in the quantitation of aortic regurgitation (AR). We hypothesized that actual measurement of PISA provided with real-time 3-dimensional (3D) color Doppler yields more accurate regurgitant volumes than those estimated by 2-dimensional (2D) color Doppler PISA. We developed a pulsatile flow model for AR with an imaging chamber in which interchangeable regurgitant orifices with defined shapes and areas were incorporated. An ultrasonic flow meter was used to calculate the reference regurgitant volumes. A total of 29 different flow conditions for 5 orifices with different shapes were tested at a rate of 72 beats/min. 2D PISA was calculated as 2π r2, and 3D PISA was measured from 8 equidistant radial planes of the 3D PISA. Regurgitant volume was derived as PISA × aliasing velocity × time velocity integral of AR/peak AR velocity. Regurgitant volumes by flow meter ranged between 12.6 and 30.6 mL/beat (mean 21.4 ± 5.5 mL/beat). Regurgitant volumes estimated by 2D PISA correlated well with volumes measured by flow meter (r = 0.69); however, a significant underestimation was observed (y = 0.5x + 0.6). Correlation with flow meter volumes was stronger for 3D PISA-derived regurgitant volumes (r = 0.83); significantly less underestimation of regurgitant volumes was seen, with a regression line close to identity (y = 0.9x + 3.9). Direct measurement of PISA is feasible, without geometric assumptions, using real-time 3D color Doppler. Calculation of aortic regurgitant volumes with 3D color Doppler using this methodology is more accurate than conventional 2D method with hemispheric PISA assumption.
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影响因子：
6.5
作者：
Sitges, M;Jones, M;Thomas, JD
通讯作者：
Thomas, JD
DOI：
10.1016/s0894-7317(03)00335-3
发表时间：
2003-07-01
影响因子：
6.5
作者：
Zoghbi, WA;Enriquez-Sarano, M;Weissman, NJ
通讯作者：
Weissman, NJ
影响因子：
37.8
作者：
SCHWAMMENTHAL, E;CHEN, CG;LEVINE, RA
通讯作者：
LEVINE, RA
DOI：
10.1016/s0735-1097(98)00356-8
发表时间：
1998-10-01
影响因子：
24
作者：
Tribouilloy, CM;Enriquez-Sarano, M;Tajik, AJ
通讯作者：
Tajik, AJ
影响因子：
4.8
作者：
RIVERA, JM;VANDERVOORT, PM;THOMAS, JD
通讯作者：
THOMAS, JD