Meta-Analytic Review of High Anxiety Comorbidity among Patients with Vitiligo.
Meta-Analytic Review of High Anxiety Comorbidity among Patients with Vitiligo.
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白癜风患者高度焦虑合并症的荟萃分析综述
DOI：
10.1155/2021/6663646
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发表时间：
2021
影响因子：
--
通讯作者：
Xiao R
中科院分区：
文献类型：
--
作者：
Liu J;Tang R;Xiao Y;Luo M;Shi Y;Deng Q;Zhang H;Zeng Z;Pi Z;Xiao R
白癜风是一种具有深刻的心理社会影响的毁容皮肤病，如焦虑，但报告的相关效应大小各不相同。我们的目的是进行一项荟萃分析，以量化焦虑和白癜风之间的关联强度，并估计焦虑在白癜风患者中的患病率。 从成立到2020年3月20日，在五个在线数据库（MEDLINE、Embase、Web of Science、科克伦图书馆和PsycInfo）中进行了系统的文献检索。对所有符合条件的研究进行了全面审查，并根据我们预定的标准对所有可用数据进行了分析。 这项荟萃分析纳入了21项研究，涉及11个国家的3259例患者。与健康对照组相比，白癜风患者常伴有焦虑（OR = 6.14 [95%CI：3.35-11.24]，I2 = 30.1%）。女性患者的合并焦虑患病率显著高于男性患者（OR = 2.24 [95%CI：1.31-3.84]，I2 = 0.0%）。亚组分析显示临床焦虑障碍和焦虑症状的合并患病率分别为12%（95%CI：7%~ 16%，I2 = 76.3%）和34%（95%CI：21%~ 46%，I2 = 94.7%）。Begg漏斗图和Egger检验未发现发表偏倚。 白癜风患者有较高的焦虑共患病率，女性占优势。皮肤科医生和精神科医生应警惕焦虑的存在，及时采取适当的干预措施，减少心理影响，从而促进白癜风患者的康复。然而，由于一些客观限制（关于OR的信息不足以及纳入研究中评估工具的多样性），应谨慎解释结果。
Vitiligo is a disfiguring skin disease with profound psychosocial impacts, such as anxiety, but the reported effect sizes of associations vary. We aimed to conduct a meta-analysis to quantify the strength of association between anxiety and vitiligo and to estimate the prevalence of anxiety among individuals with vitiligo. A systematic literature search was performed in five online databases (MEDLINE, Embase, Web of Science, Cochrane Library, and PsycINFO) from inception until March 20, 2020. All of the eligible studies were comprehensively reviewed, and all of the available data were analyzed according to our predefined criteria. Twenty-one studies involving 3259 patients in 11 countries were included in this meta-analysis. Compared with the healthy control group, patients with vitiligo often had concomitant anxiety (OR = 6.14 [95% CI: 3.35–11.24], I2 = 30.1%). The pooled prevalence of anxiety in female patients was significantly higher than that in males (OR = 2.24 [95% CI: 1.31–3.84], I2 = 0.0%). Subgroup analysis showed that the pooled prevalence of clinical anxiety disorder and anxiety symptoms was 12% (95% CI: 7%–16%, I2 = 76.3%) and 34% (95% CI: 21%–46%, I2 = 94.7%), respectively. No publication bias has been detected by Begg's funnel plot and Egger's test. Patients with vitiligo have high anxiety comorbidity, with female predominance. Dermatologists and psychiatrists should be vigilant to the presence of anxiety, apply appropriate interventions to reduce the psychological impacts in a timely manner, and thus promote recovery in vitiligo patients. However, due to some objective limitations (poor information about the OR and diversity in assessment tools among included studies), findings should be interpreted with caution.
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影响因子：
2.3
作者：
AlShahwan, Mohammed A.
通讯作者：
AlShahwan, Mohammed A.
DOI：
10.1136/bmj.b2535
发表时间：
2009-07-21
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Moher D;Liberati A;Tetzlaff J;Altman DG;PRISMA Group
通讯作者：
PRISMA Group
影响因子：
3.6
作者：
Karelson, Maire;Silm, Helgi;Kingo, Kuelli
通讯作者：
Kingo, Kuelli
影响因子：
3.6
作者：
Krueger, Christian;Schallreuter, Karin Uta
通讯作者：
Schallreuter, Karin Uta
DOI：
10.1111/jdv.15255
发表时间：
2019-01-01
影响因子：
9.2
作者：
Patel, K. R.;Singam, V.;Silverberg, J. I.
通讯作者：
Silverberg, J. I.