Sphingolipids and brain resident macrophages in neuroinflammation: an emerging aspect of nervous system pathology.
Sphingolipids and brain resident macrophages in neuroinflammation: an emerging aspect of nervous system pathology.
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DOI：
10.1155/2013/309302
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发表时间：
2013
影响因子：
--
通讯作者：
Cervia D
中科院分区：
文献类型：
--
作者：
Assi E;Cazzato D;De Palma C;Perrotta C;Clementi E;Cervia D
鞘脂代谢沿着中枢神经系统（CNS）的分化和发育而受到深度调节，并且特殊的空间和暂时调节的鞘脂模式的表达对于维持神经系统的功能完整性是必不可少的。小胶质细胞是CNS的常驻巨噬细胞，参与神经环境的一般维持。小胶质细胞表型的调节可能有助于炎症的致病形式。由于巨噬细胞/小胶质细胞活性的缺陷有助于神经退行性疾病，因此系统地鉴定有助于疾病进展的小胶质细胞反应的组分将是至关重要的。在这种复杂的过程中，鞘脂系统最近出现发挥重要作用，从而出现作为一个关键的新的球员在中枢神经系统疾病。这篇综述为利用鞘脂代谢途径作为神经炎症的潜在靶点提供了理论基础。
Sphingolipid metabolism is deeply regulated along the differentiation and development of the central nervous system (CNS), and the expression of a peculiar spatially and temporarily regulated sphingolipid pattern is essential for the maintenance of the functional integrity of the nervous system. Microglia are resident macrophages of the CNS involved in general maintenance of neural environment. Modulations in microglia phenotypes may contribute to pathogenic forms of inflammation. Since defects in macrophage/microglia activity contribute to neurodegenerative diseases, it will be essential to systematically identify the components of the microglial cell response that contribute to disease progression. In such complex processes, the sphingolipid systems have recently emerged to play important roles, thus appearing as a key new player in CNS disorders. This review provides a rationale for harnessing the sphingolipid metabolic pathway as a potential target against neuroinflammation.
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发表时间：
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影响因子：
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