Regulation of cancer invasion by reactive oxygen species and Tks family scaffold proteins.
Regulation of cancer invasion by reactive oxygen species and Tks family scaffold proteins.
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DOI：
10.1126/scisignal.288pe56
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发表时间：
2009-09-15
影响因子：
7.3
通讯作者：
Weaver AM
中科院分区：
文献类型：
--
作者：
Weaver AM
活性氧（ROS）是一种重要的信号调节因子。还原型烟酰胺腺嘌呤二核苷酸磷酸（NADPH）氧化酶（Noxs）家族负责细胞中大多数信号ROS的产生。一个新兴的范例是，单个Nox家族成员在不同的亚细胞位置被组织和激活，以实现特定的功能。酪氨酸激酶底物（Tks）家族衔接蛋白现已被鉴定为Nox组织者蛋白，其增强侵入伪足和伪足体处的ROS产生，所述侵入伪足和伪足体是与细胞外基质降解相关的亚细胞粘附结构。研究还表明，侵入伪足和足体形成也需要产生活性氧。这些发现拓宽了ROS的已知信号作用，并确定了ROS产生与癌症侵袭相关的潜在机制。
Reactive oxygen species (ROS) are increasingly recognized as important signaling regulators. The family of the reduced form of nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (Noxs) is responsible for the production of most signaling ROS in cells. An emerging paradigm is that individual Nox family members are organized and activated at distinct subcellular locations for specific functions. Tyrosine kinase substrate (Tks) family adaptor proteins have now been identified as Nox organizer proteins that enhance the production of ROS at invadopodia and podosomes, which are subcellular adhesion structures associated with extracellular matrix degradation. ROS production is also shown to be required for invadopodia and podosome formation. These findings broaden the known signaling roles of ROS and identify a potential mechanism for the correlation of ROS production with cancer invasion.
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影响因子：
3.3
作者：
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通讯作者：
Bokoch, Gary M.
DOI：
10.1016/j.bbrc.2008.12.080
发表时间：
2009-02-06
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作者：
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