Establishing diagnostic thresholds for Alzheimer's disease in adults with Down syndrome: the Cambridge Examination for Mental Disorders of Older People with Down's Syndrome and Others with Intellectual Disabilities (CAMDEX-DS).
Establishing diagnostic thresholds for Alzheimer's disease in adults with Down syndrome: the Cambridge Examination for Mental Disorders of Older People with Down's Syndrome and Others with Intellectual Disabilities (CAMDEX-DS).
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DOI：
10.1192/bjo.2021.36
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发表时间：
2021-04-13
期刊：
影响因子：
5.4
通讯作者：
Zaman SH
中科院分区：
文献类型：
--
作者：
Beresford-Webb JA;Mak E;Grigorova M;Daffern SJ;Holland AJ;Zaman SH
诊断唐氏综合症患者的前驱阿尔茨海默病和阿尔茨海默病痴呆是一项重大挑战。剑桥患有唐氏综合症和其他智力障碍的老年人精神障碍考试 (CAMDEX-DS) 已被验证可用于诊断前驱阿尔茨海默病和阿尔茨海默病痴呆，但诊断过程缺乏指导。得出 CAMDEX-DS 知情者访谈阈值分数，以便准确诊断患有唐氏综合症的成人的前驱阿尔茨海默病和阿尔茨海默病痴呆。精神科医生将患有唐氏综合症的参与者分为无痴呆组、前驱阿尔茨海默病组和阿尔茨海默病痴呆组。受试者操作特征分析评估了 CAMDEX-DS 线人访谈所得分数的诊断准确性。 Spearman 偏相关研究了 CAMDEX-DS 评分、区域 Aβ 结合（正电子发射断层扫描）和区域皮质厚度（磁共振成像）之间的关联。与患有唐氏综合症的健康成年人相比，CAMDEX-DS 总分对阿尔茨海默病痴呆（曲线下面积 (AUC)，0.998；95% CI 0.953–0.999）和前驱阿尔茨海默病（AUC = 0.954；95% CI 0.887–0.982）的诊断性能较高。与那些有心理健康问题但没有阿尔茨海默病的人相比，CAMDEX-DS B 部分评分（表示记忆和定向能力）可以准确诊断阿尔茨海默病痴呆（AUC = 0.958；95% CI 0.892–0.984），但无法诊断前驱阿尔茨海默病。 CAMDEX-DS 总分与特定区域的皮质 Aβ（r ~ 0.4 至 0.6，P ≤ 0.05）和厚度（r ~ -0.4 至 -0.44，P ≤ 0.05）表现出中等相关性。 CAMDEX-DS 总分可准确诊断患有唐氏综合症的健康成人中的阿尔茨海默病痴呆和前驱阿尔茨海默病。
Diagnosis of prodromal Alzheimer's disease and Alzheimer's disease dementia in people with Down syndrome is a major challenge. The Cambridge Examination for Mental Disorders of Older People with Down's Syndrome and Others with Intellectual Disabilities (CAMDEX-DS) has been validated for diagnosing prodromal Alzheimer's disease and Alzheimer's disease dementia, but the diagnostic process lacks guidance. To derive CAMDEX-DS informant interview threshold scores to enable accurate diagnosis of prodromal Alzheimer's disease and Alzheimer's disease dementia in adults with Down syndrome. Psychiatrists classified participants with Down syndrome into no dementia, prodromal Alzheimer's disease and Alzheimer's disease dementia groups. Receiver operating characteristic analyses assessed the diagnostic accuracy of CAMDEX-DS informant interview-derived scores. Spearman partial correlations investigated associations between CAMDEX-DS scores, regional Aβ binding (positron emission tomography) and regional cortical thickness (magnetic resonance imaging). Diagnostic performance of CAMDEX-DS total scores were high for Alzheimer's disease dementia (area under the curve (AUC), 0.998; 95% CI 0.953–0.999) and prodromal Alzheimer's disease (AUC = 0.954; 95% CI 0.887–0.982) when compared with healthy adults with Down syndrome. When compared with those with mental health conditions but no Alzheimer's disease, CAMDEX-DS Section B scores, denoting memory and orientation ability, accurately diagnosed Alzheimer's disease dementia (AUC = 0.958; 95% CI 0.892–0.984), but were unable to diagnose prodromal Alzheimer's disease. CAMDEX-DS total scores exhibited moderate correlations with cortical Aβ (r ~ 0.4 to 0.6, P ≤ 0.05) and thickness (r ~ −0.4 to −0.44, P ≤ 0.05) in specific regions. CAMDEX-DS total score accurately diagnoses Alzheimer's disease dementia and prodromal Alzheimer's disease in healthy adults with Down syndrome.
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影响因子：
4.9
作者：
Mullins D;Daly E;Simmons A;Beacher F;Foy CM;Lovestone S;Hallahan B;Murphy KC;Murphy DG
通讯作者：
Murphy DG
影响因子：
168.9
作者：
Fortea, Juan;Vilaplana, Eduard;Lleo, Alberto
通讯作者：
Lleo, Alberto
影响因子：
3.6
作者：
McCarron, M.;McCallion, P.;Mulryan, N.
通讯作者：
Mulryan, N.
DOI：
10.1111/j.1365-2788.2004.00630.x
发表时间：
2004-09-01
影响因子：
3.6
作者：
Ball, SL;Holland, AJ;Hon, J
通讯作者：
Hon, J
DOI：
10.1016/j.jalz.2015.07.490
发表时间：
2016-05
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
Annus T;Wilson LR;Hong YT;Acosta-Cabronero J;Fryer TD;Cardenas-Blanco A;Smith R;Boros I;Coles JP;Aigbirhio FI;Menon DK;Zaman SH;Nestor PJ;Holland AJ
通讯作者：
Holland AJ