Does sexual functioning improve with migraine improvements and/or weight loss?-A post hoc analysis in the Women's Health and Migraine (WHAM) trial.
Does sexual functioning improve with migraine improvements and/or weight loss?-A post hoc analysis in the Women's Health and Migraine (WHAM) trial.
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性功能会随着偏头痛改善和/或体重减轻而改善吗？ - 妇女健康和偏头痛（WHAM）试验中的事后分析。
DOI：
10.1002/osp4.443
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发表时间：
2020-12
影响因子：
2.2
通讯作者：
Bond D
中科院分区：
文献类型：
--
作者：
Schumacher L;Wing R;Thomas JG;Pavlovic J;Digre K;Farris S;Steffen K;Sarwer D;Bond D
尽管偏头痛可能导致女性性功能受损，但数据并不一致，并指出肥胖是一个潜在的混杂因素。评估偏头痛改善和减肥与性功能相关的相对重要性的前瞻性研究可能有助于阐明偏头痛、肥胖和女性性功能障碍(FSD)之间的联系。评价偏头痛或偏头痛教育(ME)后行为减肥(BWL)干预后的性功能变化和改善的预测因素。偏头痛和超重/肥胖的女性被随机分为16周BWL组(n=54)和ME组(n=56)。参与者在治疗前和治疗后完成了为期4周的智能手机头痛日记和女性性功能指数(FSFI)。经过验证的FSFI总分界值定义的FSD。我们比较了不同情况下FSFI评分和FSD比率的变化，并评估了偏头痛的改善和体重减轻作为全样本中性功能的预测指标。在完成治疗的85人中，56名(65.9%)在治疗前和治疗后报告有性行为的参与者被分析。不同情况下偏头痛的改善情况相似，而与ME相比，BWL的体重减轻更大。FSD率总体上没有变化(48.2%到44.6%，p=.66)，也没有按情况变化(BWL：56.0%到40.0%，而ME：41.9%到48.4%，p=.17)。在FSFI总分和分量表分数的变化上也观察到了类似的模式。在不同情况下，较大的体重减轻预示着FSFI总分和觉醒分量表得分的更大改善，而较大的偏头痛头痛频率减少预示着FSFI满意度分量表得分的更大改善。BWL或ME的性功能没有改善，尽管偏头痛在BWL后两种情况下都有所改善，体重也有所减轻。然而，体重减轻与性反应(即唤醒)的生理成分和整体性功能的改善有关，而头痛频率的减少与性满意度的提高有关。还需要用更大的样本进行进一步的研究。
Despite plausibility of migraine headaches contributing to impaired sexual function among women, data are inconsistent and point to obesity as a potential confounder. Prospective studies that assess the relative importance of migraine improvements and weight loss in relation to sexual function could help elucidate associations among migraine, obesity and female sexual dysfunction (FSD). To evaluate sexual function changes and predictors of improvement after behavioural weight loss (BWL) intervention for migraine or migraine education (ME). Women with migraine and overweight/obesity were randomized to 16 weeks of BWL (n = 54) or ME (n = 56). Participants completed a 4‐week smartphone headache diary and the Female Sexual Function Index (FSFI) at pre‐ and post‐treatment. A validated FSFI total cut‐off score defined FSD. We compared changes in FSFI scores and FSD rates between conditions and evaluated migraine improvements and weight loss as predictors of sexual functioning in the full sample. Among treatment completers (n = 85), 56 (65.9%) participants who reported sexual activity at pre‐ and post‐treatment were analysed. Migraine improvements were similar between conditions, whereas BWL had greater weight losses compared with ME. FSD rates did not change overall (48.2% to 44.6%, p = .66) or by condition (BWL: 56.0% to 40.0% vs. ME: 41.9% to 48.4%, p = .17). Similar patterns were observed for changes in FSFI total and subscale scores. Across conditions, larger weight losses predicted greater improvements in FSFI total and arousal subscale scores, whereas larger migraine headache frequency reductions predicted greater improvements in FSFI satisfaction subscale scores. Sexual functioning did not improve with either BWL or ME despite migraine headache improvements in both conditions and weight loss after BWL. However, weight loss related to improvements in physiological components of the sexual response (i.e., arousal) and overall sexual functioning, whereas reduced headache frequency related to improved sexual satisfaction. Additional research with larger samples is needed.
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影响因子：
5
作者：
Bond DS;Pavlović JM;Lipton RB;Graham Thomas J;Digre KB;Roth J;Rathier L;O'Leary KC;Evans EW;Wing RR
通讯作者：
Wing RR
影响因子：
2.7
作者：
Dindo, Lilian;Recober, Ana;Turvey, Carolyn
通讯作者：
Turvey, Carolyn
影响因子：
4.9
作者：
Holroyd, K. A.;Drew, J. B.;Heh, V.
通讯作者：
Heh, V.
偏头痛和超重/肥胖女性的头痛残疾和疼痛干扰有关的疼痛接受的重要性。
影响因子：
5
作者：
Lillis J;Graham Thomas J;Seng EK;Lipton RB;Pavlović JM;Rathier L;Roth J;O'Leary KC;Bond DS
通讯作者：
Bond DS
影响因子：
2.9
作者：
Janik, Michal Robert;Bielecka, Ilona;Pasnik, Krzysztof;Kwiatkowski, Andrzej;Podgorska, Ludmia
通讯作者：
Podgorska, Ludmia