Case series analysis of adverse reactions to vaccines: a comparative evaluation.
Case series analysis of adverse reactions to vaccines: a comparative evaluation.
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疫苗不良反应病例系列分析：比较评价。
DOI：
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发表时间：
1996
影响因子：
5
通讯作者：
Elizabeth Miller
中科院分区：
文献类型：
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作者：
C. Farrington;J. Nash;Elizabeth Miller
已经提出了一种改进的队列方法来估计接种疫苗后罕见不良反应的相对发生率。该方法只需要一个病例样本，从而避免了跟踪大的人群队列或选择对照的需要。在疫苗接种后风险期短、疫苗覆盖率高的情况下，该病例系列方法具有与全队列方法相当的统计能力。该方法还消除了与疫苗接种结果和避免接种有关的变量的混淆。本文回顾了队列方法、病例对照方法和病例序列方法，并比较了它们的基本假设和性能。理论结果是使用英国接种麻疹-腮腺炎-风疹疫苗后热性惊厥的数据来说明的。
A modified cohort method has been proposed for estimating the relative incidence of rare adverse reactions after vaccination. The method requires only a sample of the cases, thus avoiding the need for following large population cohorts or selecting controls. This case series method has statistical power equivalent to that of the full cohort method when the risk periods after vaccination are short and vaccine coverage is high. The method also eliminates confounding by variables associated with both the outcome and avoidance of vaccination. In this paper, the cohort, case-control, and case series methods are reviewed, and their underlying assumptions and performances are compared. Theoretical results are illustrated using data on febrile convulsions after measles-mumps-rubella vaccination in the United Kingdom.
影响因子：
5
作者：
MACLURE, M
通讯作者：
MACLURE, M