Pathological features and survival outcomes of young patients with operable colon cancer: are they homogeneous?
Pathological features and survival outcomes of young patients with operable colon cancer: are they homogeneous?
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可手术结肠癌年轻患者的病理特征和生存结果：它们是否同质？
DOI：
10.1371/journal.pone.0102004
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Cai S
中科院分区：
文献类型：
--
作者：
Li Q;Zhuo C;Cai G;Zheng H;Li D;Cai S
比较不同年龄亚组青年结肠癌患者的病理特征和生存结局。使用监测、流行病学和最终结果（SEER）基于人群的数据，我们确定了1988年至2005年间诊断为结肠癌并接受手术治疗的2，861例年轻患者。患者分为4组：组1（25岁以下）、组2（26-30岁）、组3（31-35岁）和组4（36-40岁）。获得了5年癌症特异性生存数据。采用Kaplan-Meier方法，建立多因素考克斯回归模型，分析长期生存结局及危险因素。四组间在病理分级、组织学类型、AJCC分期、现行标准（≥12个淋巴结）、平均检查淋巴结数和阳性淋巴结数等方面差异有显著性（p<0.001）。5年病因特异性生存率分别为71.0%、75.1%、80.6%和82.5%。单因素分析（P = 0.002）和多因素分析（P = 0.041）差异均有统计学意义。 18-40岁的年轻结肠癌患者基本上是一个异质性群体。年龄在31-35岁、36-40岁的患者比年龄在30岁以下的患者具有更有利的临床病理特征和更好的癌症特异性生存。
To compare the pathological features and survival outcomes at different age subgroups of young patients with colon cancer. Using Surveillance, Epidemiology, and End Results (SEER) population-based data, we identified 2,861 young patients with colon cancer diagnosed between 1988 and 2005 treated with surgery. Patients were divided into four groups: group 1 (below 25 years), group 2 (26–30 years), group 3 (31–35 years) and group 4 (36–40 years). Five-year cancer specific survival data were obtained. Kaplan-Meier methods were adopted and multivariable Cox regression models were built for the analysis of long-term survival outcomes and risk factors. There were significant different among four groups in pathological grading, histological type, AJCC stage, current standard (≥12 lymph nodes retrieval), mean number of lymph nodes examined and positive lymph nodes (p<0.001). The 5-year cause specific survival was 71.0% in group 1, 75.1% in group 2, 80.6% in group 3 and 82.5% in group 4, which had significant difference in both univariate (P = 0.002) and multivariate analysis (P = 0.041). Young patients with colon cancer at age 18–40 years are essentially a heterogeneous group. Patients at age 31–35, 36–40 subgroups have more favorable clinicopathologic characteristics and better cancer specific survival than below 30 years.
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将转移淋巴结与检查淋巴结的比率以及转移淋巴结数量纳入 AJCC 结肠癌分期系统
影响因子：
3.7
作者：
Gao P;Song YX;Wang ZN;Xu YY;Tong LL;Zhu JL;Tang QC;Xu HM
通讯作者：
Xu HM
影响因子：
2.2
作者：
Li, Ming;Li, Ji-You;Gu, Jin
通讯作者：
Gu, Jin
影响因子：
6.4
作者：
Gondos, Adam;Hiripi, Eva;Brenner, Hermann
通讯作者：
Brenner, Hermann
影响因子：
45.3
作者：
Anders, Carey K.;Hsu, David S.;Blackwell, Kimberly L.
通讯作者：
Blackwell, Kimberly L.
影响因子：
3.3
作者：
Neufeld, D.;Shpitz, B.;Ziv, Y.
通讯作者：
Ziv, Y.