How the neurocircuitry and genetics of fear inhibition may inform our understanding of PTSD.
How the neurocircuitry and genetics of fear inhibition may inform our understanding of PTSD.
复制标题
DOI：
10.1176/appi.ajp.2009.09071074
复制
发表时间：
2010-06
期刊：
影响因子：
--
通讯作者：
Ressler KJ
中科院分区：
文献类型：
--
作者：
Jovanovic T;Ressler KJ
暴露在造成极端恐惧和恐怖的创伤事件中在军人和平民中都很常见，但并不是所有人都会因为暴露而患上创伤后应激障碍(PTSD)。在创伤后应激障碍和其他应激相关精神病理学的发展过程中，调节风险和韧性的因素对于我们进一步理解创伤相关精神病理学以及开发新的治疗方法至关重要。生物因素，如基因和神经生物学，与环境因素相互作用，如童年背景和创伤负荷，影响创伤暴露后的脆弱性和复原力。创伤后应激障碍的核心症状之一是无法控制恐惧，这导致一些研究人员和临床医生将创伤后应激障碍概念化为恐惧障碍，或者更重要的是，它是一种抑制。本文综述了创伤后应激障碍中恐惧条件作用和恐惧抑制的翻译方法，并总结了与恐惧抑制相关的遗传和神经生物学因素。作者还讨论了增强恐惧抑制并可能改善创伤后应激障碍患者治疗结果的不同药理学方法。
Exposure to traumatic events that produce extreme fear and horror is all too common in both military and civilian populations, but not all individuals develop posttraumatic stress disorder (PTSD) as a result of the exposure. What mediates risk and resilience in the development of PTSD and other stress-related psychopathology is of paramount importance to our further understanding of trauma-related psychopathology as well as the development of new treatment approaches. Biological factors, such as genotype and neurobiology, interact with environmental factors, such as childhood background and trauma load, to affect vulnerability and resilience in the aftermath of trauma exposure. One of the core symptoms of PTSD is the inability to control fear, which has led some investigators and clinicians to conceptualize PTSD as a disorder of fear or, more importantly, its inhibition. This review focuses on translational methods that have been used to examine fear conditioning and inhibition of fear in PTSD and summarizes genetic and neurobiological factors related to fear inhibition. The authors also discuss different pharmacological approaches that enhance fear inhibition and may improve treatment outcomes for patients with PTSD.
登录
查看更多内容
DOI：
10.1098/rstb.1997.0149
发表时间：
1997-11-29
期刊：
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES
影响因子：
--
作者：
Davis, M;Walker, DL;Lee, Y
通讯作者：
Lee, Y
影响因子：
120.7
作者：
Binder, Elisabeth B.;Bradley, Rebekah G.;Ressler, Kerry J.
通讯作者：
Ressler, Kerry J.
影响因子：
6.9
作者：
Bremner, JD;Vermetten, E;Charney, DS
通讯作者：
Charney, DS
影响因子：
5.3
作者：
Chhatwal, JP;Myers, KM;Davis, M
通讯作者：
Davis, M
影响因子：
2
作者：
Cain, CK;Godsil, BP;Barad, M
通讯作者：
Barad, M