Reproductive decision-making in families containing multiple individuals with epilepsy.
Reproductive decision-making in families containing multiple individuals with epilepsy.
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作者：
Nakamura J;Sorge ST;Winawer MR;Phelan JC;Chung WK;Ottman R
评估多个癫痫患者家庭中影响生育决策的因素。149名成年癫痫患者和149名来自多个受影响个体家庭的未患癫痫的成年生物学亲属完成了一份自填问卷。参与者回答了关于他们对癫痫遗传原因（遗传归因）的信念以及受影响者后代癫痫风险的估计问题。参与者对影响他们生育计划的因素进行了评级，回答从“更有可能”到“不太可能”想要一个孩子。那些癫痫患者被问到：“如果你没有癫痫，你认为你会想要更多的孩子吗？”癫痫患者的后代比他们未受影响的亲属少（平均1.2比1.9，p=0.002），这种差异在已婚者中持续存在。患有癫痫的参与者中受影响父母的后代患癫痫的风险估计值高于无癫痫的亲属（平均值27.2 vs. 19.6，p=0.002）。19%的癫痫患者回答说，如果他们没有癫痫，他们会想要更多的孩子。25%的癫痫患者回答说，“有一个孩子患有癫痫的机会”或“在你的家庭中患有癫痫”使他们不太可能想要一个孩子。有这些遗传问题与受影响父母的后代中更大的遗传归因和估计的癫痫风险显着相关。癫痫患者比没有癫痫的生物学亲属有更少的孩子。关于癫痫遗传原因的信念有助于限制生育的担忧和决定。这些信念应该在遗传咨询中得到解决，以确保后代和生殖选择的真正风险得到充分理解。
To evaluate factors influencing reproductive decision-making in families containing multiple individuals with epilepsy. One hundred forty-nine adults with epilepsy and 149 adult biological relatives without epilepsy from families containing multiple affected individuals completed a self-administered questionnaire. Participants answered questions regarding their belief in a genetic cause of epilepsy (genetic attribution) and estimated risk of epilepsy in an offspring of an affected person. Participants rated factors for their influence on their reproductive plans, with responses ranging from “much more likely” to “much less likely” to want to have a child. Those with epilepsy were asked, “Do you think you would have wanted more (or any) children if you had not had epilepsy?” Participants with epilepsy had fewer offspring than their unaffected relatives (mean 1.2 vs. 1.9, p=0.002), and this difference persisted among persons who had been married. Estimates of risk of epilepsy in an offspring of an affected parent were higher among participants with epilepsy than among relatives without epilepsy (mean 27.2 vs. 19.6, p=0.002). Nineteen percent of participants with epilepsy responded that they would have wanted more children if they had not had epilepsy. Twenty-five percent of participants with epilepsy responded that “the chance of having a child with epilepsy” or “having epilepsy in your family” made them less likely to want to have a child. Having these genetic concerns was significantly associated with greater genetic attribution and estimated risk of epilepsy in offspring of an affected parent. People with epilepsy have fewer children than their biological relatives without epilepsy. Beliefs about genetic causes of epilepsy contribute to concerns and decisions to limit child-bearing. These beliefs should be addressed in genetic counseling to ensure that true risks to offspring and reproductive options are well understood.
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影响因子：
5.6
作者：
Sorge ST;Hesdorffer DC;Phelan JC;Winawer MR;Shostak S;Goldsmith J;Chung WK;Ottman R
通讯作者：
Ottman R
影响因子：
5
作者：
Artama, M;Isojärvi, JIT;Auvinen, A
通讯作者：
Auvinen, A
影响因子：
2.6
作者：
Vazquez, Blanca;Gibson, Patricia;Kustra, Robert
通讯作者：
Kustra, Robert
影响因子：
5.6
作者：
Ottman, R;Berenson, K;Barker-Cummings, C
通讯作者：
Barker-Cummings, C
影响因子：
5.6
作者：
Garofalo, Diana C.;Sorge, Shawn T.;Ottman, Ruth
通讯作者：
Ottman, Ruth