The Hydra Holobiont: A Tale of Several Symbiotic Lineages
The Hydra Holobiont: A Tale of Several Symbiotic Lineages
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Hydra Holobiont：几个共生谱系的故事
DOI：
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发表时间：
2016
期刊：
影响因子：
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通讯作者：
David J. Miller
中科院分区：
文献类型：
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作者：
T. Bosch;David J. Miller
2000年夏天，当基尔大学的皮肤科医生Jens Schroder在动物学新主席就职典礼上询问Hydra是否是研究上皮防御生物化学的良好模型系统时，我们中的一个人（TB）开始认识到有益微生物的重要性。当时没有人会预料到，这引发了比较和进化免疫学中一个新模型系统的发展。在此之前，海德拉一直致力于在进化背景下研究发育机制，并揭示模式形成和干细胞调控的基本原理。我们没有想到免疫反应是动物同样重要的特征。像九头蛇这样简单的多细胞动物的进化意味着发明发育途径来塑造和维持给定的身体计划，并终生保护这个身体，而理解这一背景的一部分需要理解九头蛇进化的生物和非生物环境，这是令人启发和兴奋的。本章将展示我们对水螅中宿主-微生物相互作用的了解程度，以及这些发现在更广泛的全息生物研究背景下的意义。
The personal journey of one of us (TB) toward the realization that beneficial microbes are important began in summer 2000 when Jens Schroder, a dermatologist at Kiel University, on the occasion of the inauguration of the new chair of Zoology asked if Hydra were not a good model system to investigate the biochemistry of epithelial defenses. Nobody at that time would have anticipated that this triggered the development of a novel model system in comparative and evolutionary immunology. Up to that moment, Hydra was all for examining developmental mechanisms in an evolutionary context and to uncover basic principles of pattern formation and stem cell regulation. To think of immune reactions as equally important features of an animal did not come to our mind. That evolution of a simple multicellular animal such as Hydra means both invention of developmental pathways to shape and maintain a given body plan and also to protect this body all life long, and understanding that part of that context requires understanding the biotic and abiotic environment in which Hydra evolved turned out to be enlightening and exciting. This chapter will show just how much we know about host–microbe interactions in Hydra and what these findings mean in a more general context of holobiont research.
影响因子：
64.8
作者：
Becker, Thomas;Loch, Gerrit;Hoch, Michael
通讯作者：
Hoch, Michael
影响因子：
11
作者：
Fraune, Sebastian;Anton-Erxleben, Friederike;Bosch, Thomas C. G.
通讯作者：
Bosch, Thomas C. G.