Global gene expression during the human organogenesis: from transcription profiles to function predictions.
Global gene expression during the human organogenesis: from transcription profiles to function predictions.
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DOI：
10.7150/ijbs.7.1068
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发表时间：
2011
影响因子：
9.2
通讯作者：
Li WX
中科院分区：
文献类型：
--
作者：
Xue L;Yi H;Huang Z;Shi YB;Li WX
人类胚胎发育包括一组复杂而协调的不同器官和组织的发育，受许多基因的时空表达调控。破译基因调控谱对于理解人类胚胎发育的分子基础至关重要。虽然小鼠的分子和遗传学研究已经成为了解哺乳动物发育的宝贵工具，但在形态和基因组水平上，人和小鼠的发育存在显著差异。因此，直接开展人类胚胎发育研究具有重要意义。在这里，我们将对人类胚胎发育过程中基因调控的一些最新研究进行综述，尤其是器官发生时期，这方面的研究以前没有得到很好的研究。我们将重点介绍从第4周到第9周的人类胚胎基因表达数据库。对这一时期基因调控的分析表明，在特定的发育过程中，基因的功能往往在人类胚胎发育过程中受到协调调控。这一特征使我们能够利用这个数据库来识别对特定发育过程/途径重要的新基因，并推断新基因在器官发生过程中的潜在功能。这样的基因表达图谱应该成为人类发育和发病机制分子研究的重要资源。
Human embryogenesis includes an integrated set of complex yet coordinated development of different organs and tissues, which is regulated by the spatiotemporal expression of many genes. Deciphering the gene regulation profile is essential for understanding the molecular basis of human embryo development. While molecular and genetic studies in mouse have served as a valuable tool to understand mammalian development, significant differences exists in human and mouse development at morphological and genomic levels. Thus it is important to carry out research directly on human embryonic development. Here we will review some recent studies on gene regulation during human embryogenesis with particular focus on the period of organogenesis, which had not been well studied previously. We will highlight a gene expression database of human embryos from the 4th to the 9th week. The analysis of gene regulation during this period reveals that genes functioning in a given developmental process tend to be coordinately regulated during human embryogenesis. This feature allows us to use this database to identify new genes important for a particular developmental process/pathway and deduce the potential function of a novel gene during organogenesis. Such a gene expression atlas should serve as an important resource for molecular study of human development and pathogenesis.
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DOI：
10.1016/j.ejogrb.2004.01.026
发表时间：
2004-07-01
影响因子：
2.6
作者：
Tanaka, TS;Ko, MSH
通讯作者：
Ko, MSH
影响因子：
9.8
作者：
Church DM;Goodstadt L;Hillier LW;Zody MC;Goldstein S;She X;Bult CJ;Agarwala R;Cherry JL;DiCuccio M;Hlavina W;Kapustin Y;Meric P;Maglott D;Birtle Z;Marques AC;Graves T;Zhou S;Teague B;Potamousis K;Churas C;Place M;Herschleb J;Runnheim R;Forrest D;Amos-Landgraf J;Schwartz DC;Cheng Z;Lindblad-Toh K;Eichler EE;Ponting CP;Mouse Genome Sequencing Consortium
通讯作者：
Mouse Genome Sequencing Consortium
DOI：
10.1073/pnas.0402597101
发表时间：
2004-07-13
影响因子：
11.1
作者：
Hamatani, T;Daikoku, T;Dey, SK
通讯作者：
Dey, SK
DOI：
10.1073/pnas.0603227103
发表时间：
2006-09-19
影响因子：
11.1
作者：
Kocabas, Arif Murat;Crosby, Javier;Cibelli, Jose Bernardo
通讯作者：
Cibelli, Jose Bernardo
影响因子：
64.8
作者：
BRAUDE, P;BOLTON, V;MOORE, S
通讯作者：
MOORE, S