Structural, mechanical and osmotic properties of injectable hyaluronan-based composite hydrogels.
Structural, mechanical and osmotic properties of injectable hyaluronan-based composite hydrogels.
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DOI：
10.1016/j.polymer.2010.06.027
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发表时间：
2010-09-03
期刊：
影响因子：
4.6
通讯作者：
Zarembinski, Thomas
中科院分区：
文献类型：
--
作者：
Horkay, Ferenc;Magda, Jules;Alcoutlabi, Mataz;Atzet, Sarah;Zarembinski, Thomas
研究了由刚性生物聚合物链（羧甲基化硫代透明质酸（CMHA-S））与柔性聚合物（聚乙二醇二丙烯酸酯（PEGDA））交联而成的透明质酸基复合水凝胶的渗透和散射特性。凝胶前聚合物总质量浓度在0.5 wt.% ~ 3.2 wt.%之间变化，而反应性PEG链端与硫代HA部分的摩尔比在0.15 ~ 1.0之间变化。完全膨胀凝胶的剪切模量G对凝胶前浓度的依赖性大于对交联密度的依赖性。渗透溶胀测量表明，渗透混合压力取决于CMHA-S/PEGDA的质量比，而实际上不受凝胶前浓度的影响。小角中子散射观测表明，这些复合凝胶的热力学性质受聚合物总浓度的影响，即两种聚合物组分之间的特定相互作用不起显著作用。
The osmotic and scattering properties of hyaluronan-based composite hydrogels composed of stiff biopolymer chains (carboxymethylated thiolated hyaluronan (CMHA-S)) crosslinked by a flexible polymer (polyethylene glycol diacrylate (PEGDA)) are investigated and analyzed in terms of the scaling theory. The total pre-gel polymer weight concentration is varied between 0.5 wt.% and 3.2 wt.%, while the mole ratio between the reactive PEG chain ends and the thiolated HA moieties is changed between 0.15 and 1.0. The shear modulus G of the fully swollen gels exhibits a stronger dependence on pre-gel concentration than on the crosslink density. Osmotic deswelling measurements reveal that the osmotic mixing pressure depends on the weight ratio CMHA-S/PEGDA, and is practically unaffected by the pre-gel concentration. Small-angle neutron scattering observations indicate that the thermodynamic properties of these composite gels are governed by total polymer concentration, i.e., specific interactions between the two polymeric components do not play a significant role.
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影响因子：
4.6
作者：
Horkay, F;Basser, PJ;Geissler, E
通讯作者：
Geissler, E
影响因子：
5.5
作者：
DEGENNES, PG
通讯作者：
DEGENNES, PG
影响因子：
5.5
作者：
DEGENNES, PG
通讯作者：
DEGENNES, PG
影响因子：
2.6
作者：
Klemuk, SA;Titze, IR
通讯作者：
Titze, IR
影响因子：
3.2
作者：
RIVLIN, RS
通讯作者：
RIVLIN, RS