Involvement of insulin-like growth factor-1 in the effect of caloric restriction: regulation of plasma adiponectin and leptin.
Involvement of insulin-like growth factor-1 in the effect of caloric restriction: regulation of plasma adiponectin and leptin.
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胰岛素样生长因子-1 参与热量限制的影响：血浆脂联素和瘦素的调节。
DOI：
10.1093/gerona/62.1.27
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
I. Shimokawa
中科院分区：
文献类型：
--
作者：
H. Yamaza;Toshimitsu Komatsu;Kazuo To;Hiroaki Toyama;T. Chiba;Y. Higami;I. Shimokawa
Insulin-like growth factor (IGF)-1 signaling might partly mediate effects of caloric restriction (CR), an experimental intervention for increasing longevity in mammals. The present study evaluated effects of recombinant human (rh)IGF-1 infusion on adipokine levels in CR and transgenic (Tg) dwarf rats with the reduced growth hormone-IGF-1 axis, which shared similar body weight and food intake. At 9 months of age, each rat received a continuous infusion of rhIGF-1 for 14 days, and rats received an injection of glucose after overnight fasting. Infusion of rhIGF-1 had metabolic effects in all rat groups although it did not affect insulin sensitivity in any of the groups. In addition, plasma adiponectin was decreased to the control group levels and plasma leptin was further reduced in CR and Tg rats. The similarity of phenotypes and adipokine responses to rhIGF-1 between CR and Tg rats supports a role for reduced IGF-1 signaling in the CR effect.
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生长激素释放从外源性胰岛素样生长因子 I (IGF-I) 的抑制中恢复：游离而不是结合的 IGF-I 具有抑制作用的证据。
DOI：
10.1210/jcem.83.8.5040
发表时间：
1998
期刊：
The Journal of clinical endocrinology and metabolism.
影响因子：
--
作者：
Chapman,IM;Hartman,ML;Pieper,KS;Skiles,EH;Pezzoli,SS;Hintz,RL;Thorner,MO
通讯作者：
Thorner,MO
影响因子：
15.9
作者：
Sinha, MK;Opentanova, I;Caro, JF
通讯作者：
Caro, JF
DOI：
10.1016/s0021-9258(18)34631-3
发表时间：
1982-05
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
J. Massagué;M. Czech
通讯作者：
J. Massagué;M. Czech
DOI：
10.1073/pnas.93.8.3434
发表时间：
1996-04
影响因子：
11.1
作者：
T. M. Mizuno;H. Bergen;Toshiya Funabashi;S. Kleopoulos;Y. Zhong;W. Bauman;C. Mobbs
通讯作者：
T. M. Mizuno;H. Bergen;Toshiya Funabashi;S. Kleopoulos;Y. Zhong;W. Bauman;C. Mobbs
衰老和饮食限制对组织蛋白合成的影响：与血浆胰岛素样生长因子-1 的关系。
DOI：
10.1093/geronj/47.5.b159
发表时间：
1992
期刊：
Journal of gerontology
影响因子：
--
作者：
Sonntag,WE;Lenham,JE;Ingram,RL
通讯作者：
Ingram,RL