miR-425 regulates lipophagy via SIRT1 to promote sorafenib resistance in liver cancer.
miR-425 regulates lipophagy via SIRT1 to promote sorafenib resistance in liver cancer.
复制标题
miR-425通过SIRT1调控脂噬，促进肝癌索拉非尼耐药。
DOI：
10.3892/ol.2021.12956
复制
发表时间：
2021-10
期刊：
影响因子：
2.9
通讯作者：
Li H
中科院分区：
文献类型：
--
作者：
Sun G;Yang L;Wei S;Jin H;Li B;Li H
Liver cancer is one of the most malignant cancer, with poor outcomes and a high incidence rate, and current treatment approaches to prevent tumor progression and development remain unsatisfactory. Therefore, it is urgent to explore novel methods to inhibit tumor growth and metastasis. Autophagy is a highly conserved process associated with metastasis and drug resistance. Lipids are selectively recognized and degraded via autophagy; thus, autophagy is a crucial process to maintain tumor self-protection. MicroRNA (miR)-425 is a tumor-associated gene involved in liver cancer development that can induce cell proliferation and drug resistance. Using Cell Counting Kit-8 assays, western blot analysis and immunofluorescence assays, the present study revealed that inhibition of miR-425 promoted lipophagy by mediating the autophagy process, which in turn helps to promote sorafenib resistance. Using a bioinformatics website, it was revealed that autophagy promoted lipophagy by targeting silent information regulator 2 homolog 1 (SIRT1). The results of luciferase reporter assays supported this finding, and rescue experiments provided additional evidence. Overall, the current results suggested that inhibition of miR-425 expression increased SIRT1 expression to promote lipophagy, leading to the inhibition of liver cancer cell proliferation.
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DOI：
10.1016/j.bbrc.2018.02.097
发表时间：
2018-10-07
影响因子：
3.1
作者：
Maan M;Peters JM;Dutta M;Patterson AD
通讯作者：
Patterson AD
影响因子：
8.8
作者：
Sathyanarayan A;Mashek MT;Mashek DG
通讯作者：
Mashek DG
影响因子：
11.2
作者：
Li, HR;Shagisultanova, EI;Malkhosyan, SR
通讯作者：
Malkhosyan, SR
影响因子：
5.2
作者：
Regan-Fendt K;Li D;Reyes R;Yu L;Wani NA;Hu P;Jacob ST;Ghoshal K;Payne PRO;Motiwala T
通讯作者：
Motiwala T
通过自噬调节脂质液滴。
影响因子：
10.9
作者：
Dong, Hanqing;Czaja, Mark J.
通讯作者：
Czaja, Mark J.