Lipid metabolism and lipophagy in cancer.
Lipid metabolism and lipophagy in cancer.
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DOI：
10.1016/j.bbrc.2018.02.097
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发表时间：
2018-10-07
影响因子：
3.1
通讯作者：
Patterson AD
中科院分区：
文献类型：
--
作者：
Maan M;Peters JM;Dutta M;Patterson AD
肿瘤微环境可能是低氧、酸性和缺乏营养的。这可以导致肿瘤细胞以及邻近基质细胞的代谢被重塑，以促进肿瘤的存活、增殖和转移。肿瘤脂质代谢异常是一个相当新的领域，近年来受到关注。肿瘤细胞和肿瘤相关基质细胞之间的串扰调节肿瘤的高代谢需求。肿瘤细胞中的脂肪酸周转率很高，以满足生长肿瘤的能量和合成需求。早期认为储存在脂滴中的脂质的脂肪分解仅由胞质脂肪酶进行。然而，最近的研究表明，脂肪自噬（酸性脂肪酶对脂质的自噬降解）是脂滴降解的替代途径。脂质吞噬参与脂质周转，使其在肿瘤发生和转移中发挥关键作用。在这篇综述中，我们讨论了肿瘤细胞的代谢重编程，特别关注脂质代谢。我们还研究了肿瘤细胞中的脂质周转机制，特别是噬脂途径。最后，我们将目前对脂肪吞噬的理解与肿瘤脂质代谢结合起来。
The tumor microenvironment can be hypoxic, acidic, and deficient in nutrients. This can cause the metabolism of tumor cells as well as the neighboring stromal cells to be remodelled to facilitate tumor survival, proliferation, and metastasis. Abnormal tumor lipid metabolism is a fairly new field, which has received attention in the past few years. Cross-talk between tumor cells and tumor associated stromal cells modulates the high metabolic needs of the tumor. Fatty acid turnover is high in tumor cells to meet the energy as well as synthetic requirements of the growing tumor. Lipolysis of lipids stored in lipid droplets was earlier considered to be solely carried out by cytosolic lipases. However recent studies demonstrate that lipophagy (autophagic degradation of lipids by acidic lipases) serves as an alternate pathway for the degradation of lipid droplets. Involvement of lipophagy in lipid turnover makes it a crucial player in tumorigenesis and metastasis. In this review we discuss the metabolic reprogramming of tumor cells with special focus on lipid metabolism. We also address the lipid turnover machinery in the tumor cell, especially the lipophagic pathway. Finally, we integrate the current understanding of lipophagy with tumor lipid metabolism.
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影响因子：
7.3
作者：
Gao J;Aksoy BA;Dogrusoz U;Dresdner G;Gross B;Sumer SO;Sun Y;Jacobsen A;Sinha R;Larsson E;Cerami E;Sander C;Schultz N
通讯作者：
Schultz N
影响因子：
64.5
作者：
Cubillos-Ruiz JR;Silberman PC;Rutkowski MR;Chopra S;Perales-Puchalt A;Song M;Zhang S;Bettigole SE;Gupta D;Holcomb K;Ellenson LH;Caputo T;Lee AH;Conejo-Garcia JR;Glimcher LH
通讯作者：
Glimcher LH
影响因子：
29
作者：
Corbet, Cyril;Pinto, Adan;Feron, Olivier
通讯作者：
Feron, Olivier
影响因子：
9.9
作者：
Gaglio, Daniela;Metallo, Christian M.;Chiaradonna, Ferdinando
通讯作者：
Chiaradonna, Ferdinando
影响因子：
6
作者：
Du, Hong;Zhao, Ting;Yan, Cong
通讯作者：
Yan, Cong