Epidemiology of Any and Vaccine-Type Anogenital Human Papillomavirus Among 13-26-Year-Old Young Men After HPV Vaccine Introduction.
Epidemiology of Any and Vaccine-Type Anogenital Human Papillomavirus Among 13-26-Year-Old Young Men After HPV Vaccine Introduction.
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DOI：
10.1016/j.jadohealth.2018.01.005
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发表时间：
2018-07
期刊：
影响因子：
--
通讯作者：
Kahn JA
中科院分区：
文献类型：
--
作者：
Chandler E;Ding L;Gorbach P;Franco EL;Brown DA;Widdice LE;Bernstein DI;Kahn JA
本研究的目的是确定任何人乳头瘤病毒（HPV）和疫苗型HPV在疫苗引入后的年轻男性中的患病率和相关因素，按疫苗接种状态分层。从2013年至2015年，从临床研究中心招募了年轻男性，完成了一项调查，并对36种肛门生殖器HPV类型进行了检测。我们使用多变量回归确定了所有参与者中与> 1种HPV类型相关的因素，以及所有接种疫苗和未接种疫苗的参与者中的疫苗型HPV（HPV 6，11，16和/或18）。平均年龄为21.5岁，26%的人接受过至少一剂HPV疫苗。接种疫苗的年轻男性HPV感染率低于未接种疫苗的年轻男性（50.5% vs. 62.6%，p=.03）。各研究中心的HPV阳性率不一致。两个研究中心的HPV型别≥ 1个的阳性率为59.4%，四价疫苗型别≥ 1个的阳性率为26.0%。多因素Logistic回归分析显示，与所有受试者中≥ 1种HPV类型相关的因素为口交频率（OR=1.80，95%CI =1.00-3.24）、近期吸烟（OR=1.84，CI=1.17-2.90）和性传播感染史（OR=1.56，CI=1.02-2.38）。所有参与者中与疫苗型HPV相关的因素是白色与黑人（OR=1.91，CI=1.10-3.34）和淋病史（OR=2.52，CI=1.45-4.38）;在接种疫苗的参与者中，（OR=5.6，CI=1.46-20.4）和私人与无保险（OR=15.9，CI=3.06-83.3）;未接种疫苗的参与者中有淋病史（OR=1.83，CI=1.03-3.24）。在疫苗引入后的两到四年内，年轻男性的肛门生殖器HPV患病率很高，疫苗接种率很低，这强调了根据国家指南提高疫苗接种率和接种疫苗的紧迫性。
The aims of this study were to determine prevalence of and factors associated with any human papillomavirus (HPV) and vaccine-type HPV among young men after vaccine introduction, stratified by vaccination status. Young men were recruited from clinical sites from 2013–2015, completed a survey, and were tested for 36 anogenital HPV types. We determined factors associated with > 1 HPV type among all participants, and vaccine-type HPV (HPV6, 11, 16, and/or 18) among all, vaccinated and unvaccinated participants, using multivariable regression. Mean age was 21.5 years and 26% had received at least one HPV vaccine dose. HPV prevalence was lower in vaccinated vs. unvaccinated young men (50.5% vs. 62.6%, p=.03). HPV positivity was discordant by site. At both sites, 59.4% were positive for ≥ 1 HPV type and 26.0% for ≥ 1 4-valent vaccine type. In multivariable logistic regression, factors associated with ≥ 1 HPV type among all participants were frequency of oral sex (OR=1.80, 95% CI=1.00–3.24), recent smoking (OR=1.84, CI=1.17–2.90), and sexually transmitted infection history (OR=1.56, CI=1.02–2.38). Factors associated with vaccine-type HPV among all participants were White vs. Black race (OR=1.91, CI=1.10–3.34) and gonorrhea history (OR=2.52, CI=1.45–4.38); among vaccinated participants were private vs. Medicaid insurance (OR=5.6, CI=1.46–20.4) and private vs. no insurance (OR=15.9, CI=3.06–83.3); and among unvaccinated participants was gonorrhea history (OR=1.83, CI=1.03–3.24). Anogenital HPV prevalence was high and vaccination rates low among young men two to four years after vaccine introduction, underscoring the urgency of increasing vaccination rates and vaccinating according to national guidelines.
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影响因子：
3.6
作者：
Kofoed, Kristian;Sand, Carsten;Madsen, Klaus
通讯作者：
Madsen, Klaus
DOI：
10.1056/nejmoa0909537
发表时间：
2011-02-03
期刊：
The New England journal of medicine
影响因子：
--
作者：
Giuliano AR;Palefsky JM;Goldstone S;Moreira ED Jr;Penny ME;Aranda C;Vardas E;Moi H;Jessen H;Hillman R;Chang YH;Ferris D;Rouleau D;Bryan J;Marshall JB;Vuocolo S;Barr E;Radley D;Haupt RM;Guris D
通讯作者：
Guris D
影响因子：
11.2
作者：
Chaturvedi, Anil K.;Graubard, Barry I.;Gillison, Maura L.
通讯作者：
Gillison, Maura L.
影响因子：
33.9
作者：
Reagan-Steiner, Sarah;Yankey, David;Singleton, James A.
通讯作者：
Singleton, James A.
影响因子：
6.4
作者：
Goldstone, Stephen;Palefsky, Joel M.;Garner, Elizabeth I. O.
通讯作者：
Garner, Elizabeth I. O.