The Growth Hormone Receptor: Mechanism of Receptor Activation, Cell Signaling, and Physiological Aspects.
The Growth Hormone Receptor: Mechanism of Receptor Activation, Cell Signaling, and Physiological Aspects.
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DOI：
10.3389/fendo.2018.00035
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发表时间：
2018
影响因子：
5.2
通讯作者：
Brooks AJ
中科院分区：
文献类型：
--
作者：
Dehkhoda F;Lee CMM;Medina J;Brooks AJ
生长激素受体（GHR），虽然最为人所知的是调节生长，但具有许多其他重要的生物学功能，包括调节代谢和控制与肝胆、心血管、肾、胃肠道和生殖系统相关的生理过程。此外，生长激素信号是衰老的重要调节因子，在癌症发展中起着重要作用。生长激素激活Janus激酶（JAK）-信号转导子和转录激活子（STAT）信号通路，最近的研究对生长激素与其受体结合激活JAK 2的机制提供了新的认识。JAK 2活化是生长激素介导的STAT 1、STAT 3和STAT 5活化所必需的，并且JAK-STAT信号传导的负调节包括控制该信号传导途径的重要步骤。GHR还激活不依赖于JAK 2的Src家族激酶信号通路。本文综述了GHR激活和信号转导的分子机制以及生长激素信号转导的生理后果。
The growth hormone receptor (GHR), although most well known for regulating growth, has many other important biological functions including regulating metabolism and controlling physiological processes related to the hepatobiliary, cardiovascular, renal, gastrointestinal, and reproductive systems. In addition, growth hormone signaling is an important regulator of aging and plays a significant role in cancer development. Growth hormone activates the Janus kinase (JAK)–signal transducer and activator of transcription (STAT) signaling pathway, and recent studies have provided a new understanding of the mechanism of JAK2 activation by growth hormone binding to its receptor. JAK2 activation is required for growth hormone-mediated activation of STAT1, STAT3, and STAT5, and the negative regulation of JAK–STAT signaling comprises an important step in the control of this signaling pathway. The GHR also activates the Src family kinase signaling pathway independent of JAK2. This review covers the molecular mechanisms of GHR activation and signal transduction as well as the physiological consequences of growth hormone signaling.
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影响因子：
1.4
作者：
Biener-Ramanujan, Eva;Ramanujan, V. Krishnan;Gertler, Arieh
通讯作者：
Gertler, Arieh
影响因子：
64.5
作者：
BAKER, J;LIU, JP;EFSTRATIADIS, A
通讯作者：
EFSTRATIADIS, A
影响因子：
4.8
作者：
Barbour, LA;Rahman, SM;Draznin, B
通讯作者：
Draznin, B
影响因子：
4.8
作者：
BEHRINGER, RR;LEWIN, TM;DERCOLE, AJ
通讯作者：
DERCOLE, AJ
DOI：
10.1111/j.1365-2362.1990.tb01857.x
发表时间：
1990-06-01
影响因子：
5.5
作者：
BANG, P;BRANDT, J;HALL, K
通讯作者：
HALL, K