MSiReader v1.0: Evolving Open-Source Mass Spectrometry Imaging Software for Targeted and Untargeted Analyses.
MSiReader v1.0: Evolving Open-Source Mass Spectrometry Imaging Software for Targeted and Untargeted Analyses.
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MSIREADER v1.0：为目标和非目标分析而发展的开源质谱成像软件。
DOI：
10.1007/s13361-017-1809-6
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发表时间：
2018-01
影响因子：
3.2
通讯作者：
Muddiman DC
中科院分区：
文献类型：
--
作者：
Bokhart MT;Nazari M;Garrard KP;Muddiman DC
介绍了质谱学成像(MSI)软件MSiReader的重大更新，提供了许多对MSI分析至关重要的新功能。MSiReader是一个免费的、开源的、独立于供应商的软件，它是在MatLab平台上编写的，能够分析大多数常见的MSI数据格式。该软件的独立版本也被分发，该软件不需要MATLAB许可证。新加入的数据分析功能扩展了MSiReader的用途，使其超越了简单的分子分布可视化。MSiQuantiation工具允许研究人员仅通过MSiReader软件计算量化MSI实验的绝对浓度，大大减少了数据分析时间。图像覆盖功能允许将互补成像模式与MSI数据一起显示。数据加载步骤中还集成了一个极性过滤器，使得在将数据文件加载到MSiReader之前无需进行数据解析即可轻松分析极性切换实验。还增加了为感兴趣的分析物生成质量测量精度(MMA)热图的质量保证功能，以允许在成像实验中对MMA进行调查。最重要的是，随着新功能的添加，性能并没有下降，事实上，它得到了极大的改善。这些新工具和MSiReader v1.0中对性能的改进使MSI社区能够更深入、更短地评估他们的数据。
A major update to the mass spectrometry imaging (MSI) software MSiReader is presented, offering a multitude of newly added features critical to MSI analyses. MSiReader is a free, open-source, and vendor-neutral software written in the MATLAB platform and is capable of analyzing most common MSI data formats. A standalone version of the software which does not require a MATLAB license is also distributed. The newly incorporated data analysis features expand the utility of MSiReader beyond simple visualization of molecular distributions. The MSiQuantification tool allows researchers to calculate absolute concentrations from quantification MSI experiments exclusively through MSiReader software, significantly reducing data analysis time. An image overlay feature allows the incorporation of complementary imaging modalities to be displayed with the MSI data. A polarity filter has also been incorporated into the data loading step, allowing the facile analysis of polarity switching experiments without the need for data parsing prior to loading the data file into MSiReader. A quality assurance feature to generate a mass measurement accuracy (MMA) heatmap for an analyte of interest has also been added to allow for the investigation of MMA across the imaging experiment. Most importantly, as new features have been added performance has not degraded, in fact it has been dramatically improved. These new tools and the improvements to the performance in MSiReader v1.0 enable the MSI community to evaluate their data in greater depth and in less time.
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DOI：
10.1039/c5an01513h
发表时间：
2016-01-21
期刊：
The Analyst
影响因子：
--
作者：
Nazari M;Muddiman DC
通讯作者：
Muddiman DC
影响因子：
16.6
作者：
Liebeke M;Strittmatter N;Fearn S;Morgan AJ;Kille P;Fuchser J;Wallis D;Palchykov V;Robertson J;Lahive E;Spurgeon DJ;McPhail D;Takáts Z;Bundy JG
通讯作者：
Bundy JG
影响因子：
4.3
作者：
Bokhart, Mark T.;Rosen, Elias;Thompson, Corbin;Sykes, Craig;Kashuba, Angela D. M.;Muddiman, David C.
通讯作者：
Muddiman, David C.
影响因子：
3.3
作者：
Schramm, Thorsten;Hester, Alfons;Roempp, Andreas
通讯作者：
Roempp, Andreas
影响因子：
48
作者：
Palmer, Andrew;Phapale, Prasad;Alexandrov, Theodore
通讯作者：
Alexandrov, Theodore