Mother's education and offspring asthma risk in 10 European cohort studies.
Mother's education and offspring asthma risk in 10 European cohort studies.
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DOI：
10.1007/s10654-017-0309-0
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发表时间：
2017-09
影响因子：
13.6
通讯作者：
Pikhart H
中科院分区：
文献类型：
--
作者：
Lewis KM;Ruiz M;Goldblatt P;Morrison J;Porta D;Forastiere F;Hryhorczuk D;Zvinchuk O;Saurel-Cubizolles MJ;Lioret S;Annesi-Maesano I;Vrijheid M;Torrent M;Iniguez C;Larranaga I;Harskamp-van Ginkel MW;Vrijkotte TGM;Klanova J;Svancara J;Barross H;Correia S;Jarvelin MR;Taanila A;Ludvigsson J;Faresjo T;Marmot M;Pikhart H
哮喘非常普遍，通常始于儿童时期，是一种负担沉重的疾病，但这种疾病的危险因素尚不清楚。为了加强理解，本研究评估了10个欧洲国家3-8岁儿童哮喘的母亲教育的队列特异性和汇总风险。研究人员从10个欧洲国家的前瞻性出生队列研究中获得了47099名儿童的数据。我们使用相对不平等指数（RII）和不平等斜率指数（SII）计算哮喘结局的队列特异性患病率差异。所有国家的结果采用随机效应荟萃分析程序进行汇总，以获得欧洲水平的平均RII和SII分数。最后的模型根据儿童性别、怀孕期间吸烟、胎次、母亲年龄和种族进行了调整。得分越高，相对（RII，文献1）和绝对（SII，文献0）不平等程度越大。所有队列哮喘风险的综合RII估计值为1.46 (95% CI 1.26, 1.71)，综合SII估计值为1.90 （95% CI 0.26, 3.54）。在接受调查的国家中，法国、英国和荷兰的儿童哮喘患病率最高，哮喘风险的不平等程度也最大。除意大利外，其他所有国家都存在较小的负相关关系，意大利的得分相互矛盾，但效应大小较小。异质性测试对SII得分产生了显著的结果。总的来说，与受过高等教育的母亲的后代相比，受教育程度低的母亲的后代患哮喘的相对和绝对风险都增加。
Highly prevalent and typically beginning in childhood, asthma is a burdensome disease, yet the risk factors for this condition are not clarified. To enhance understanding, this study assessed the cohort-specific and pooled risk of maternal education on asthma in children aged 3–8 across 10 European countries. Data on 47,099 children were obtained from prospective birth cohort studies across 10 European countries. We calculated cohort-specific prevalence difference in asthma outcomes using the relative index of inequality (RII) and slope index of inequality (SII). Results from all countries were pooled using random-effects meta-analysis procedures to obtain mean RII and SII scores at the European level. Final models were adjusted for child sex, smoking during pregnancy, parity, mother’s age and ethnicity. The higher the score the greater the magnitude of relative (RII, reference 1) and absolute (SII, reference 0) inequity. The pooled RII estimate for asthma risk across all cohorts was 1.46 (95% CI 1.26, 1.71) and the pooled SII estimate was 1.90 (95% CI 0.26, 3.54). Of the countries examined, France, the United Kingdom and the Netherlands had the highest prevalence’s of childhood asthma and the largest inequity in asthma risk. Smaller inverse associations were noted for all other countries except Italy, which presented contradictory scores, but with small effect sizes. Tests for heterogeneity yielded significant results for SII scores. Overall, offspring of mothers with a low level of education had an increased relative and absolute risk of asthma compared to offspring of high-educated mothers.
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影响因子：
5
作者：
Galobardes B;Granell R;Sterne J;Hughes R;Mejia-Lancheros C;Davey Smith G;Henderson J
通讯作者：
Henderson J
影响因子：
6.1
作者：
Almqvist, C;Pershagen, G;Wickman, M
通讯作者：
Wickman, M
影响因子：
5.5
作者：
Borrell, Carme;Palencia, Laia;O'Campo, Patricia
通讯作者：
O'Campo, Patricia
影响因子：
5.4
作者：
Goddard, M;Smith, P
通讯作者：
Smith, P
影响因子：
24.3
作者：
Cesaroni, G;Farchi, S;Perucci, CA
通讯作者：
Perucci, CA