A feasible strategy for self-assembly of gold nanoparticles via dithiol-PEG for photothermal therapy of cancers.
A feasible strategy for self-assembly of gold nanoparticles via dithiol-PEG for photothermal therapy of cancers.
复制标题
通过二硫醇-PEG自组装金纳米粒子用于癌症光热治疗的可行策略
DOI:
10.1039/c7ra12735a
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发表时间:
2018-02-02
期刊:
影响因子:
3.9
通讯作者:
Zhou, Xiang
中科院分区:
文献类型:
--
作者:
Fu, Yingjie;Feng, Qishuai;Shen, Yajing;Chen, Mengwei;Xu, Chang;Cheng, Yu;Zhou, Xiang
We designed and explored self-assembled gold nanoparticles (SAGNPs) by introducing dithiol modified polyethylene glycol (PEG) for internanoparticle cross-linking. SAGNPs could enhance uptake into cancer cells and be disintegrated by glutathione (GSH) to achieve tumor microenvironment-activated biodegradation. This assembled structure improved the photothermal effect compared to single gold nanospheres.
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通讯作者:
Nordlander, P