Renal function and cognition in the 1932 Scottish Mental Survey Lothian cohort.
Renal function and cognition in the 1932 Scottish Mental Survey Lothian cohort.
复制标题
1932 年苏格兰心理调查洛锡安队列中的肾功能和认知。
作者：
L. Munang;J. Starr;L. Whalley;I. Deary
先生——严重尿毒症与认知障碍和痴呆有关 [1, 2]。在中等水平下，血清肌酐升高与血管性痴呆风险增加相关，但与阿尔茨海默病无关[3]。这种增加归因于通常伴有中度肾功能损害的心血管疾病，但调整心血管危险因素并不能完全消除这种关联。 [3]。任何肾脏-认知障碍关联都可能反映微血管疾病[4]，特别是与脑白质病变相关的微血管疾病[5]。尽管在更年期女性中发现了这种关联，但关于老年人正常范围内的认知功能和肾功能之间的关联的数据却很少[6]。即使存在关联，因果关系的方向仍然不确定。众所周知，智商较低的儿童在中年时血压较高，即使在调整了社会阶层、吸烟和性别之后也是如此 [7]，而这反过来可能会导致以后的肾功能下降。因此，尚不清楚先前的认知能力是否有助于后来的肾功能或是否存在相互影响。我们在一组独特的老年人中研究了肾功能和认知功能之间的关联，这些老年人拥有生命早期的心理能力数据，可以阐明潜在的因果路径。
Sir—Severe uraemia is associated with cognitive impairment and dementia [1, 2]. At a moderate level, elevated serum creatinine is associated with an increased risk of vascular dementia, though not Alzheimer’s disease [3]. This increase has been attributed to cardiovascular disease that often accompanies moderate renal impairment, but adjusting for cardiovascular risk factors does not completely abolish the association. [3]. It is possible that any renal-cognitive impairment association reflects microvascular disease [4], in particular, that associated with cerebral white matter lesions [5]. There is a paucity of data about any association between cognitive function and renal function within the normal range in older people, though an association was found for menopausal women [6]. Even if an association exists, direction of causality remains undetermined. Children with lower IQs are known to have higher blood pressures in middle age, even after adjusting for social class, smoking and gender [7], and this, in turn, may lead to later decrements in renal function. Thus, it is not clear whether prior cognitive ability contributes to later renal function or whether there is reciprocal influence. We investigated the association between renal function and cognitive function in a unique cohort of older people who had early life mental ability data that allowed potential causal pathways to be elucidated.
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影响因子：
--
作者：
Curhan, GC;Willett, WC;Stampfer, M
通讯作者：
Stampfer, M
DOI：
10.1097/01.asn.0000131529.60019.fa
发表时间：
2004-07-01
影响因子：
13.6
作者：
Seliger, SL;Siscovick, DS;Kuller, LH
通讯作者：
Kuller, LH
影响因子：
13.2
作者：
Edwards, MS;Wilson, DB;Hansen, KJ
通讯作者：
Hansen, KJ
影响因子：
13.2
作者：
Sehgal, AR;Grey, SF;Whitehouse, PJ
通讯作者：
Whitehouse, PJ