Cohort profile: a collaborative multicentre study of retinal optical coherence tomography in 539 patients with neuromyelitis optica spectrum disorders (CROCTINO).
Cohort profile: a collaborative multicentre study of retinal optical coherence tomography in 539 patients with neuromyelitis optica spectrum disorders (CROCTINO).
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队列概况：对 539 名视神经脊髓炎谱系疾病 (CROCTINO) 患者进行视网膜光学相干断层扫描的多中心协作研究。
DOI：
10.1136/bmjopen-2019-035397
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发表时间：
2020-10-29
期刊：
影响因子：
2.9
通讯作者：
GJCF International Clinical Consortium for NMOSD
中科院分区：
文献类型：
--
作者：
Specovius S;Zimmermann HG;Oertel FC;Chien C;Bereuter C;Cook LJ;Lana Peixoto MA;Fontenelle MA;Kim HJ;Hyun JW;Jung SK;Palace J;Roca-Fernandez A;Diaz AR;Leite MI;Sharma SM;Ashtari F;Kafieh R;Dehghani A;Pourazizi M;Pandit L;Dcunha A;Aktas O;Ringelstein M;Albrecht P;May E;Tongco C;Leocani L;Pisa M;Radaelli M;Martinez-Lapiscina EH;Stiebel-Kalish H;Hellmann M;Lotan I;Siritho S;de Seze J;Senger T;Havla J;Marignier R;Tilikete C;Cobo Calvo A;Bichuetti DB;Tavares IM;Asgari N;Soelberg K;Altintas A;Yildirim R;Tanriverdi U;Jacob A;Huda S;Rimler Z;Reid A;Mao-Draayer Y;de Castillo IS;Yeaman MR;Smith TJ;Brandt AU;Paul F;GJCF International Clinical Consortium for NMOSD
光学相干断层扫描（OCT）捕捉视网膜损伤的神经脊髓炎视谱障碍（NMOSD）。由于疾病的稀缺性和异质性，以往研究OCT在NMOSD中的应用受到限制。本研究的目的是建立一个图像库平台，以促进NMOSD的神经影像学研究。在这里，我们总结了NMOSD存储库中协作OCT的概况，作为建立该平台的初步努力。对于使用OCT调查NMOSD的研究来说，这个资源库应该证明是无价的。目前的队列包括539名NMOSD患者和114名健康对照者的数据。这些数据是在北美、南美、亚洲和欧洲的22个参与中心收集的。该数据集包括人口统计细节、诊断、抗体状态、临床残疾、视觉功能、视神经炎史和其他NMOSD定义攻击，以及来自三种不同OCT设备的OCT源数据。该队列提供了与先前发表的NMOSD队列相似的人口统计学和临床特征。图像库平台和中心网络继续可用于未来NMOSD的前瞻性神经影像学研究。为了进行这项研究，我们改进了OCT图像质量标准，并开发了一个跨设备的视网膜内分割管道。我们正在进行几个基于资料库的科学项目，例如分析视网膜层厚度测量，在这个队列中，试图确定不同疾病表型、人口统计学和种族之间的差异。该数据集将提供给有兴趣的、合格的各方，如使用专业图像分析或人工智能应用程序的各方，用于进一步的项目。
Optical coherence tomography (OCT) captures retinal damage in neuromyelitis optica spectrum disorders (NMOSD). Previous studies investigating OCT in NMOSD have been limited by the rareness and heterogeneity of the disease. The goal of this study was to establish an image repository platform, which will facilitate neuroimaging studies in NMOSD. Here we summarise the profile of the Collaborative OCT in NMOSD repository as the initial effort in establishing this platform. This repository should prove invaluable for studies using OCT to investigate NMOSD. The current cohort includes data from 539 patients with NMOSD and 114 healthy controls. These were collected at 22 participating centres from North and South America, Asia and Europe. The dataset consists of demographic details, diagnosis, antibody status, clinical disability, visual function, history of optic neuritis and other NMOSD defining attacks, and OCT source data from three different OCT devices. The cohort informs similar demographic and clinical characteristics as those of previously published NMOSD cohorts. The image repository platform and centre network continue to be available for future prospective neuroimaging studies in NMOSD. For the conduct of the study, we have refined OCT image quality criteria and developed a cross-device intraretinal segmentation pipeline. We are pursuing several scientific projects based on the repository, such as analysing retinal layer thickness measurements, in this cohort in an attempt to identify differences between distinct disease phenotypes, demographics and ethnicities. The dataset will be available for further projects to interested, qualified parties, such as those using specialised image analysis or artificial intelligence applications.
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DOI：
10.1212/nxi.0000000000000131
发表时间：
2015-08
期刊：
Neurology(R) neuroimmunology & neuroinflammation
影响因子：
--
作者：
Chalmoukou K;Alexopoulos H;Akrivou S;Stathopoulos P;Reindl M;Dalakas MC
通讯作者：
Dalakas MC
影响因子：
3.4
作者：
Borisow N;Mori M;Kuwabara S;Scheel M;Paul F
通讯作者：
Paul F
DOI：
10.1177/1352458514567216
发表时间：
2015-05
期刊：
Multiple sclerosis (Houndmills, Basingstoke, England)
影响因子：
--
作者：
Bennett JL;de Seze J;Lana-Peixoto M;Palace J;Waldman A;Schippling S;Tenembaum S;Banwell B;Greenberg B;Levy M;Fujihara K;Chan KH;Kim HJ;Asgari N;Sato DK;Saiz A;Wuerfel J;Zimmermann H;Green A;Villoslada P;Paul F;GJCF-ICC&BR
通讯作者：
GJCF-ICC&BR
影响因子：
4
作者：
Brandt, Alexander U.;Specovius, Svenja;Costello, Fiona
通讯作者：
Costello, Fiona
影响因子：
11
作者：
Costello, Fiona;Pan, Y. Irene;Kardon, Randy
通讯作者：
Kardon, Randy