Neuromyelitis optica and multiple sclerosis: Seeing differences through optical coherence tomography.
Neuromyelitis optica and multiple sclerosis: Seeing differences through optical coherence tomography.
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DOI：
10.1177/1352458514567216
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发表时间：
2015-05
期刊：
影响因子：
--
通讯作者：
GJCF-ICC&BR
中科院分区：
文献类型：
--
作者：
Bennett JL;de Seze J;Lana-Peixoto M;Palace J;Waldman A;Schippling S;Tenembaum S;Banwell B;Greenberg B;Levy M;Fujihara K;Chan KH;Kim HJ;Asgari N;Sato DK;Saiz A;Wuerfel J;Zimmermann H;Green A;Villoslada P;Paul F;GJCF-ICC&BR
视神经脊髓炎(NMO)是一种中枢神经系统炎症性自身免疫性疾病，主要累及视神经和脊髓。临床表现可能提示多发性硬化症(MS)，但高达80%的NMO患者中存在的针对星形细胞水通道蛋白-4的高度特异性血清自身抗体使其能够与MS区分开来。光学相干断层扫描(OCT)已成为分析MS和NMO视网膜损伤的有用工具。大量研究表明，与MS相比，NMO的视神经炎通常会导致更严重的视网膜神经纤维层(RNFL)和节细胞层变薄，以及更常见的黄斑微囊性水肿。此外，虽然MS患者没有视神经炎时也会发生RNFL变薄，但NMO的亚临床损害似乎很少见。因此，OCT可能有助于区分NMO和MS，并可作为临床研究的结果参数。
Neuromyelitis optica (NMO) is an inflammatory autoimmune disease of the central nervous system that preferentially targets the optic nerves and spinal cord. The clinical presentation may suggest multiple sclerosis (MS), but a highly specific serum autoantibody against the astrocytic water channel aquaporin-4 present in up to 80% of NMO patients enables distinction from MS. Optic neuritis may occur in either condition resulting in neuro-anatomical retinal changes. Optical coherence tomography (OCT) has become a useful tool for analyzing retinal damage both in MS and NMO. Numerous studies showed that optic neuritis in NMO typically results in more severe retinal nerve fiber layer (RNFL) and ganglion cell layer thinning and more frequent development of microcystic macular edema than in MS. Furthermore, while patients’ RNFL thinning also occurs in the absence of optic neuritis in MS, subclinical damage seems to be rare in NMO. Thus, OCT might be useful in differentiating NMO from MS and serve as an outcome parameter in clinical studies.
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