Acidic calcium stores open for business: expanding the potential for intracellular Ca2+ signaling.

Acidic calcium stores open for business: expanding the potential for intracellular Ca2+ signaling.
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DOI:
10.1016/j.tcb.2010.02.003
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发表时间:
2010-05
影响因子:
19
通讯作者:
Docampo, Roberto
Docampo, Roberto
中科院分区:
生物学1区
文献类型:
--
作者:
Patel, Sandip;Docampo, Roberto

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Changes in cytosolic calcium concentration are crucial for a variety of cellular processes in all cells. It has long been appreciated that calcium is stored and released from intracellular calcium stores such as the endoplasmic reticulum. However, emerging evidence indicates that calcium is also dynamically regulated by a seemingly disparate collection of acidic organelles. Here, we review the defining features of these acidic calcium stores and highlight recent progress in understanding the mechanisms of uptake and release of calcium from these stores. We also examine the nature of calcium buffering within the stores and summarize the physiological and patho-physiological significance of these ubiquitous organelles in calcium signaling.
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