Genetic variant of miR-146a rs2910164 C>G and gastric cancer susceptibility.
Genetic variant of miR-146a rs2910164 C>G and gastric cancer susceptibility.
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miR-146a rs2910164 C>G 的遗传变异与胃癌易感性。
DOI：
10.18632/oncotarget.8814
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发表时间：
2016-06-07
期刊：
影响因子：
--
通讯作者：
Wei Y
中科院分区：
文献类型：
--
作者：
Xia ZG;Yin HF;Long Y;Cheng L;Yu LJ;Guo WJ;Zhu XD;Li J;Wang YN;Yang YJ;Wang JC;Jin L;Qiu LX;Wei Y
据报道，miR-146a中的单核苷酸多态性（SNP） rs2910164 G>C与胃癌（GCa）风险增加有关。然而，结果是不确定的，特别是在亚洲人群中，这可能是由于每次研究的样本量小。为了验证这种关联并获得更精确的估计，我们在中国东部人群中进行了一项大型GCa研究，包括1,125例病例和1,196例对照。我们的结果显示，在三种遗传模型中，该SNP均与GCa风险无关[共显性模型：CG vs. CC，优势比(OR) = 0.99, 95%可信区间（95% ci）： 0.83-1.19；GG vs. CC, OR = 1.03, 95%CI: 0.81-1.32；优势模型：（CG+GG） vs. CC, OR = 1.00, 95%CI = 0.84-1.19；隐性模型：GG vs. (CG+CC), OR = 1.04, 95%CI = 0.83-1.29]。年龄、性别、吸烟状况、饮酒状况或肿瘤位置的分层分析证实了这种不显著的关联。总之，这些结果表明miR-146a SNP rs2910164可能不是中国人群中GCa的危险因素。需要更大的、设计良好的、最好是前瞻性的研究来进一步证实我们的发现。
The single nucleotide polymorphism (SNP) rs2910164 G>C within miR-146a has been reported that is associated with the increased risk of gastric cancer (GCa). However, the results are inconclusive, espicially among Asian populations, which probably due to small sample size in each single study. To validate this association and get a more precise estimation, we conducted a large GCa study including 1,125 cases and 1,196 controls in an eastern Chinese population. Our results showed that this SNP was not associated with GCa risk in either of the three genetic models [co-dominant model: CG vs. CC, odds ratio (OR) = 0.99, 95% confidence interval (95%CI): 0.83-1.19; GG vs. CC, OR = 1.03, 95%CI: 0.81-1.32; dominant model: (CG+GG) vs. CC, OR = 1.00, 95%CI = 0.84-1.19; recessive model: GG vs. (CG+CC), OR = 1.04, 95%CI = 0.83-1.29]. Stratified analysis by age, gender, smoking status, drinking status, or tumor location confirmed this non-significant association. In summary, these results suggest that the miR-146a SNP rs2910164 may not be a risk factor for GCa in this Chinese population. Larger and well-designed, preferably prospective studies are needed to further confirm our findings.
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影响因子：
12.2
作者：
Cover, Timothy L.;Peek, Richard M., Jr.
通讯作者：
Peek, Richard M., Jr.
影响因子：
3.1
作者：
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Kapoor, Rakesh
影响因子：
5.3
作者：
He, Jing;Qiu, Li-Xin;Li, Jin
通讯作者：
Li, Jin
DOI：
10.1073/pnas.0802682105
发表时间：
2008-05-20
影响因子：
11.1
作者：
Jazdzewski, Krystian;Murray, Elizabeth L.;de la Chapelle, Albert
通讯作者：
de la Chapelle, Albert
影响因子：
--
作者：
Qiu LX;He J;Cheng L;Zhou F;Wang MY;Sun MH;Zhou XY;Li J;Guo WJ;Wang YN;Yang YJ;Wang JC;Jin L;Zhu XD;Wei QY
通讯作者：
Wei QY