New Insights Into Oral Squamous Cell Carcinoma: From Clinical Aspects to Molecular Tumorigenesis.
New Insights Into Oral Squamous Cell Carcinoma: From Clinical Aspects to Molecular Tumorigenesis.
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DOI：
10.3390/ijms22052252
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发表时间：
2021-02-24
影响因子：
5.6
通讯作者：
Chang JY
中科院分区：
文献类型：
--
作者：
Chen SH;Hsiao SY;Chang KY;Chang JY
摘要口腔鳞状细胞癌（SCC）是一种常见的恶性疾病，在世界范围内尤其在台湾。早期甚至临床前阶段的检测对于降低口腔鳞状细胞癌的发病率和死亡率至关重要。流行病学和基因组关联研究有助于确定口腔鳞状细胞癌的预防、诊断和治疗方法的临床病理危险因素。对于晚期口腔鳞状细胞癌，有效的治疗对于延长生存期和提高生活质量至关重要。由于口腔鳞状细胞癌具有局部侵袭并伴有淋巴结转移的特点，因此了解口腔鳞状细胞癌的侵袭性特征，特别是在淋巴管生成方面的侵袭性特征，对于确定有效的治疗方法至关重要。越来越多的证据表明，肿瘤微环境（tumor microenvironment， TME）在肿瘤的生长、侵袭和转移中起着关键作用。最近免疫检查点抑制剂单独或联合化疗的临床成功也支持了免疫治疗在口服SCC中的治疗价值。本文从临床病理危险因素、分子肿瘤发生和TME等方面综述了口腔鳞状细胞癌基础知识的重要进展。我们还强调了我们最近在口腔鳞状细胞癌的微生物组、基因组关联研究、淋巴管生成和免疫调节方面的研究。本综述通过系统地解释来自各种临床前和临床研究的新证据，可能为口服SCC治疗提供新的见解。
Oral squamous cell carcinoma (SCC) is a prevalent malignant disease worldwide, especially so in Taiwan. Early- or even preclinical-stage detection is critical for reducing morbidity and mortality from oral SCC. Epidemiological and genome association studies are useful for identifying clinicopathological risk factors for preventive, diagnostic, and therapeutic approaches of oral SCC. For advanced oral SCC, effective treatments are critical to prolonging survival and enhancing quality of life. As oral SCC is characteristic of regional invasion with lymph node metastases, understanding the aggressive features of oral SCC, particularly in lymphangiogenesis, is essential for determining effective treatments. Emerging evidence has demonstrated that the tumor microenvironment (TME) plays a pivotal role in tumor growth, invasion, and metastases. Recent clinical successes in immune checkpoint inhibitors either alone or combined with chemotherapy have also supported the therapeutic value of immunotherapy in oral SCC. This review summarizes critical advances in basic knowledge of oral SCC from the perspective of clinicopathological risk factors, molecular tumorigenesis, and the TME. We also highlight our recent investigations on the microbiome, genome association studies, lymphangiogenesis, and immunomodulation in oral SCC. This review may provide new insights for oral SCC treatment by systematically interpreting emerging evidence from various preclinical and clinical studies.
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发表时间：
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期刊：
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影响因子：
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