Immune Actions on the Peripheral Nervous System in Pain.
Immune Actions on the Peripheral Nervous System in Pain.
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DOI：
10.3390/ijms22031448
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发表时间：
2021-02-01
影响因子：
5.6
通讯作者：
Cheung CW
中科院分区：
文献类型：
--
作者：
Liu JA;Yu J;Cheung CW
疼痛可由组织损伤、疾病和感染引起。外周神经系统(PNS)和免疫系统之间的相互作用是疼痛敏化的主要作用。作为对刺激的反应，伤害性感受器从其末端释放各种媒介，有效地激活和招募免疫细胞，而渗透的免疫细胞通过产生细胞因子、趋化因子、脂质媒介和生长因子进一步促进伤害性感受器的敏化和从急性疼痛向慢性疼痛的转变。免疫细胞不仅在疼痛的产生中发挥作用，而且通过分泌抗炎或止痛效应来促进三叉神经节的修复和疼痛的缓解。在这里，我们讨论了四种主要类型的免疫细胞(单核/巨噬细胞、中性粒细胞、肥大细胞和T细胞)在疼痛过程中作用于三叉神经节的不同作用。整合这些现有的知识将加强我们对疼痛病因的细胞变化和分子机制的理解，为开发新的治疗策略提供见解。
Pain can be induced by tissue injuries, diseases and infections. The interactions between the peripheral nervous system (PNS) and immune system are primary actions in pain sensitizations. In response to stimuli, nociceptors release various mediators from their terminals that potently activate and recruit immune cells, whereas infiltrated immune cells further promote sensitization of nociceptors and the transition from acute to chronic pain by producing cytokines, chemokines, lipid mediators and growth factors. Immune cells not only play roles in pain production but also contribute to PNS repair and pain resolution by secreting anti-inflammatory or analgesic effectors. Here, we discuss the distinct roles of four major types of immune cells (monocyte/macrophage, neutrophil, mast cell, and T cell) acting on the PNS during pain process. Integration of this current knowledge will enhance our understanding of cellular changes and molecular mechanisms underlying pain pathogenies, providing insights for developing new therapeutic strategies.
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