The human immune response to tuberculosis and its treatment: a view from the blood.
The human immune response to tuberculosis and its treatment: a view from the blood.
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DOI：
10.1111/imr.12269
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发表时间：
2015-03
影响因子：
8.7
通讯作者：
O'Garra A
中科院分区：
文献类型：
--
作者：
Cliff JM;Kaufmann SH;McShane H;van Helden P;O'Garra A
对病原体结核分枝杆菌感染后的免疫反应知之甚少，阻碍了新治疗方法的发现和诊断的改进。在过去的几年中，结核病中的血液转录特征提供了关于活动性结核病期间发生的免疫应答的知识。这种特征在大多数潜伏感染结核分枝杆菌的无症状个体中不存在（称为潜伏）。使用复杂数据的模块化和途径分析显示，现在在多项研究中，活动性结核病的特征是由干扰素诱导基因（由I型和II型干扰素信号传导组成）、髓样基因和炎症基因的过表达主导。编码B和T细胞功能的基因也下调。结核病的血液特征与放射学疾病的程度相关，并在有效治疗后减少，这表明新的改进策略可能支持诊断测定和药物治疗监测方法。该特征表明I型干扰素在活动性结核病发展中的作用以前被低估，现在已经发现了许多机制来解释I型干扰素如何阻碍对结核分枝杆菌感染的保护性反应。
The immune response upon infection with the pathogen Mycobacterium tuberculosis is poorly understood, hampering the discovery of new treatments and the improvements in diagnosis. In the last years, a blood transcriptional signature in tuberculosis has provided knowledge on the immune response occurring during active tuberculosis disease. This signature was absent in the majority of asymptomatic individuals who are latently infected with M. tuberculosis (referred to as latent). Using modular and pathway analyses of the complex data has shown, now in multiple studies, that the signature of active tuberculosis is dominated by overexpression of interferon-inducible genes (consisting of both type I and type II interferon signaling), myeloid genes, and inflammatory genes. There is also downregulation of genes encoding B and T-cell function. The blood signature of tuberculosis correlates with the extent of radiographic disease and is diminished upon effective treatment suggesting the possibility of new improved strategies to support diagnostic assays and methods for drug treatment monitoring. The signature suggested a previously under-appreciated role for type I interferons in development of active tuberculosis disease, and numerous mechanisms have now been uncovered to explain how type I interferon impedes the protective response to M. tuberculosis infection.
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影响因子：
64.8
作者：
通讯作者：
--
DOI：
10.4049/jimmunol.1200255
发表时间：
2012-06-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Desvignes L;Wolf AJ;Ernst JD
通讯作者：
Ernst JD
影响因子：
56.9
作者：
Golub, TR;Slonim, DK;Lander, ES
通讯作者：
Lander, ES
影响因子：
15.9
作者：
Dorhoi, Anca;Iannaccone, Marco;Kaufmann, Stefan H. E.
通讯作者：
Kaufmann, Stefan H. E.
DOI：
10.1126/science.1224026
发表时间：
2012-09-28
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Bogunovic D;Byun M;Durfee LA;Abhyankar A;Sanal O;Mansouri D;Salem S;Radovanovic I;Grant AV;Adimi P;Mansouri N;Okada S;Bryant VL;Kong XF;Kreins A;Velez MM;Boisson B;Khalilzadeh S;Ozcelik U;Darazam IA;Schoggins JW;Rice CM;Al-Muhsen S;Behr M;Vogt G;Puel A;Bustamante J;Gros P;Huibregtse JM;Abel L;Boisson-Dupuis S;Casanova JL
通讯作者：
Casanova JL