A Review of DNA Vaccines Against Influenza.
A Review of DNA Vaccines Against Influenza.
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DOI：
10.3389/fimmu.2018.01568
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发表时间：
2018
影响因子：
7.3
通讯作者：
Hurt AC
中科院分区：
文献类型：
--
作者：
Lee LYY;Izzard L;Hurt AC
有效接种流感疫苗的挑战正在获得更多的主流关注，因为最近的流感季节报告了全球年度疫苗接种计划的低效率。再加上可能出现的新型流感病毒导致大流行，人们越来越清楚地认识到需要有效的替代品来替代鸡蛋生产的常规疫苗。自20世纪90年代以来，针对流感的DNA疫苗一直在开发中，但最初对小鼠模型试验成功的兴奋已经被较大动物模型中相对较差的表现所冲淡。近年来，DNA疫苗在抗原和表达载体的合理设计、新型疫苗佐剂的开发、基因传递方法的创新等方面取得了长足的进步。本文综述了这些进展如何应用于最近的努力，以开发一种有效的流感DNA疫苗。
The challenges of effective vaccination against influenza are gaining more mainstream attention, as recent influenza seasons have reported low efficacy in annual vaccination programs worldwide. Combined with the potential emergence of novel influenza viruses resulting in a pandemic, the need for effective alternatives to egg-produced conventional vaccines has been made increasingly clear. DNA vaccines against influenza have been in development since the 1990s, but the initial excitement over success in murine model trials has been tempered by comparatively poor performance in larger animal models. In the intervening years, much progress has been made to refine the DNA vaccine platform—the rational design of antigens and expression vectors, the development of novel vaccine adjuvants, and the employment of innovative gene delivery methods. This review discusses how these advances have been applied in recent efforts to develop an effective influenza DNA vaccine.
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作者：
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