Are we taking full advantage of the growing number of pharmacological treatment options for osteoporosis?
Are we taking full advantage of the growing number of pharmacological treatment options for osteoporosis?
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我们是否充分利用了骨质疏松症的药理治疗选择越来越多？
DOI：
10.1016/j.coph.2014.03.006
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发表时间：
2014-06
影响因子：
4
通讯作者：
Kozloff, Kenneth M.
中科院分区：
文献类型：
--
作者：
Jepsen, Karl J.;Schlecht, Stephen H.;Kozloff, Kenneth M.
我们越来越意识到，我们骨骼老化的方式在人群内部和人群之间是不一致的。尽管我们目前无法根据个体独特的生物力学需求充分利用这些治疗方法，但市场上仍有可能出现与年龄相关的骨骼强度下降作斗争的药物治疗方案。揭示改善药物靶向递送的新分子机制非常重要；然而，这只是解决与年龄相关的骨质流失问题的一部分。为了改进目前的治疗方案，我们还必须考虑特定的生物力学机制，以确定这些分子途径最终如何影响整个骨的抗骨折性。通过提高我们对分子和生物力学机制之间关系的理解，临床医生将更好地充分利用现有的药物治疗方法。最终，这将使我们能够更有策略、更有效、更经济地降低老年人的骨折风险。为此，以下综述总结了当前治疗策略的生物力学基础，同时定义了不同的生物力学机制如何导致骨折阻力降低。希望这可以作为确定药物治疗新靶点的模板，使临床医生能够个性化护理，从而降低骨折发生率。
We are becoming increasingly aware that the manner in which our skeleton ages is not uniform within and between populations. Pharmacological treatment options with the potential to combat age-related reductions in skeletal strength continue to become available on the market, notwithstanding our current inability to fully utilize these treatments by accounting for an individual’s unique biomechanical needs. Revealing new molecular mechanisms that improve the targeted delivery of pharmaceuticals is important; however, this only addresses one part of the solution for differential age-related bone loss. To improve current treatment regimes, we must also consider specific biomechanical mechanisms that define how these molecular pathways ultimately impact whole bone fracture resistance. By improving our understanding of the relationship between molecular and biomechanical mechanisms, clinicians will be better equipped to take full advantage of the mounting pharmacological treatments available. Ultimately this will enable us to reduce fracture risk among the elderly more strategically, more effectively, and more economically. In this interest, the following review summarizes the biomechanical basis of current treatment strategies while defining how different biomechanical mechanisms lead to reduced fracture resistance. It is hoped that this may serve as a template for the identification of new targets for pharmacological treatments that will enable clinicians to personalize care so that fracture incidence may be globally reduced.
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影响因子：
2.4
作者：
Bredbenner, Todd L.;Eliason, Travis D.;Potter, Ryan S.;Mason, Robert L.;Havill, Lorena M.;Nicolella, Daniel P.
通讯作者：
Nicolella, Daniel P.
影响因子：
4
作者：
Cooper, C.;Cole, Z. A.;Holroyd, C. R.;Earl, S. C.;Harvey, N. C.;Dennison, E. M.;Melton, L. J.;Cummings, S. R.;Kanis, J. A.
通讯作者：
Kanis, J. A.
影响因子：
4
作者：
Danielson, M. E.;Beck, T. J.;Karlamangla, A. S.;Greendale, G. A.;Atkinson, E. J.;Lian, Y.;Khaled, A. S.;Keaveny, T. M.;Kopperdahl, D.;Ruppert, K.;Greenspan, S.;Vuga, M.;Cauley, J. A.
通讯作者：
Cauley, J. A.
影响因子：
39.3
作者：
Gielen, S.;Landmesser, U.
通讯作者：
Landmesser, U.
DOI：
10.1097/00005768-199908000-00002
发表时间：
1999-08-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Crossley, K;Bennell, KL;Oakes, BW
通讯作者：
Oakes, BW