Brain Mechanisms Supporting Flexible Cognition and Behavior in Adolescents With Autism Spectrum Disorder.
Brain Mechanisms Supporting Flexible Cognition and Behavior in Adolescents With Autism Spectrum Disorder.
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DOI：
10.1016/j.biopsych.2020.05.010
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发表时间：
2021-01-15
影响因子：
10.6
通讯作者：
Uddin LQ
中科院分区：
文献类型：
--
作者：
Uddin LQ
认知灵活性能够对不断变化的环境做出适当的反应，并与积极的生活成果相关。随着青春期越来越注重向独立生活的过渡，这给患有自闭症谱系障碍 (ASD) 的青少年带来了特殊的挑战，他们在面临挑战时往往难以灵活行事。本综述重点关注青春期灵活认知发展的大脑机制，以及这些神经系统在自闭症谱系障碍中如何受到影响。任务切换和设定转换的神经影像学研究为自闭症谱系障碍患者认知灵活性任务执行过程中非典型的额叶外侧和扣带中岛叶网络激活提供了证据。最近的工作还研究了内在的大脑网络动力学如何支持灵活的认知。这些动态功能连接研究为自闭症谱系障碍青少年大脑状态之间转换数量的变化以及功能连接的高度可变性提供了证据。该领域的未来方向包括使用生态和构造有效性指标的组合来解决与认知灵活性测量相关的问题。还必须分析自闭症谱系障碍执行功能能力的异质性，以确定哪些人将从有针对性的培训中受益最多，以提高灵活性。青春期激素对自闭症青少年大脑网络发育和认知成熟的影响是另一个需要进一步探索的领域。最后，双语可能与自闭症谱系障碍患者保留的认知灵活性有关这一有趣的可能性值得进一步研究。解决这些悬而未决的问题对于未来对自闭症谱系障碍青少年认知和行为灵活性的转化神经科学研究至关重要。
Cognitive flexibility enables appropriate responses to a changing environment, and is associated with positive life outcomes. Adolescence, with its increased focus on transitioning to independent living, presents particular challenges for youth with autism spectrum disorder (ASD) who often struggle to behave in a flexible way when faced with challenges. This review focuses on brain mechanisms underlying the development of flexible cognition during adolescence, and how these neural systems are affected in ASD. Neuroimaging studies of task switching and set-shifting provide evidence for atypical lateral frontoparietal and midcingulo-insular network activation during cognitive flexibility task performance in individuals with ASD. Recent work also examines how intrinsic brain network dynamics support flexible cognition. These dynamic functional connectivity studies provide evidence for alterations in the number of transitions between brain states, as well as hyper-variability of functional connections in adolescents with ASD. Future directions for the field include addressing issues related to measurement of cognitive flexibility using a combination of metrics with ecological and construct validity. Heterogeneity of executive function ability in ASD must also be parsed in order to determine which individuals will benefit most from targeted training to improve flexibility. The influence of pubertal hormones on brain network development and cognitive maturation in adolescents with ASD is another area requiring further exploration. Finally, the intriguing possibility that bilingualism might be associated with preserved cognitive flexibility in ASD should be further examined. Addressing these open questions will be critical for future translational neuroscience investigations of cognitive and behavioral flexibility in adolescents with ASD.
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影响因子：
3.8
作者：
BallabanGil, K;Rapin, I;Shinnar, S
通讯作者：
Shinnar, S
影响因子：
4.7
作者：
Chai, Lucy R.;Khambhati, Ankit N.;Bassett, Danielle S.
通讯作者：
Bassett, Danielle S.
影响因子：
3.7
作者：
Allen, Elena A.;Damaraju, Eswar;Calhoun, Vince D.
通讯作者：
Calhoun, Vince D.
DOI：
10.1196/annals.1412.011
发表时间：
2007-01-01
期刊：
SOCIAL COGNITIVE NEUROSCIENCE OF ORGANIZATIONS
影响因子：
--
作者：
Bailey, Charles E.
通讯作者：
Bailey, Charles E.
影响因子：
16.2
作者：
Calhoun, Vince D.;Miller, Robyn;Pearlson, Godfrey;Adali, Tulay
通讯作者：
Adali, Tulay