Type 1 diabetes and COVID-19: The "lockdown effect".
Type 1 diabetes and COVID-19: The "lockdown effect".
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DOI：
10.1016/j.diabres.2020.108468
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发表时间：
2020-12
影响因子：
5.1
通讯作者：
Del Prato S
中科院分区：
文献类型：
--
作者：
Aragona M;Rodia C;Bertolotto A;Campi F;Coppelli A;Giannarelli R;Bianchi C;Dardano A;Del Prato S
本研究的目的是评估COVID-19爆发期间实施的封锁对使用连续（CGM）或快速葡萄糖监测（FGM）控制1型糖尿病（T1 D）患者血糖的影响。我们回顾性分析了T1 D受试者通过FGM或CGM获得的葡萄糖阅读。分析了锁定前2周（阶段0，P0）、锁定后2周（阶段1，P1）、锁定中期（阶段2，P2）和锁定结束后即刻（阶段3，P3）的探头数据。该研究纳入了63例T1 D患者（FGM：52例，82%; CGM：11例，18%）。传感器使用率（91%）略有下降。尽管有这种减少，但与P0（58%，所有p < 0.05或更小）相比，P1（62%）、P2（61%）和P3（62%）的范围内时间增加，同时高于范围的时间减少（与P0相比，P0：38%; P1：34%，P2：34%，P3：32%，所有p < 0.05或更小）。与P0相比，P3的平均葡萄糖和GMI改善达到统计学差异（165与158 mg/dl，p = 0.040和7.2%（55 mmol/mol）与7.0%（53 mmol/mol），p = 0.016）。低于范围的时间（TBR）和总体葡萄糖变异性保持不变。每两小时一次的葡萄糖曲线分析显示改善，尤其是在清晨。在CGM或FGM血糖控制良好的T1 D受试者中，锁定没有负面影响。记录到血糖控制的适度但显著的改善，最可能反映了更规律的日常生活活动并减少了与工作相关的痛苦。
The aim of this study was to evaluate the effect the lockdown imposed during COVID-19 outbreak on the glycemic control of people with Type 1 diabetes (T1D) using Continuous (CGM) or Flash Glucose Monitoring (FGM). We retrospectively analyzed glucose reading obtained by FGM or CGM in T1D subjects. Sensor data from 2 weeks before the lockdown (Period 0, P0), 2 weeks immediately after the lockdown (period 1, P1), in mid-lockdown (Period 2, P2) and immediately after end of lockdown (Period 3, P3) were analyzed. The study included 63 T1D patients, (FGM: 52, 82%; CGM:11, 18%). Sensor use (91%) were slightly reduced. Despite this reduction, Time in Range increased in P1 (62%), P2 (61%) and P3 (62%) as compared to P0 (58%, all p < 0.05 or less) with concomitant reduction in the Time Above Range (P0: 38%; P1: 34%, P2: 34%, P3: 32%, all p < 0.05 or less vs. P0). Average glucose and GMI improved achieving statistical difference in P3 (165 vs. 158 mg/dl, p = 0.040 and 7.2% (55 mmol/mol) vs. 7.0% (53 mmol/mol), p = 0.016) compared to P0. Time Below Range (TBR) and overall glucose variability remained unchanged. Bi-hourly analysis of glucose profile showed an improvement particularly in the early morning hours. In T1D subjects with good glycemic control on CGM or FGM, the lockdown had no negative impact. Rather a modest but significant improvement in glycemic control has been recorded, most likely reflecting more regular daily life activities and reduces work-related distress.
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影响因子：
16.2
作者：
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通讯作者：
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影响因子：
16.2
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