Complement control protein factor H: the good, the bad, and the inadequate.
Complement control protein factor H: the good, the bad, and the inadequate.
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DOI：
10.1016/j.molimm.2010.05.007
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发表时间：
2010-08
影响因子：
3.6
通讯作者：
Cortés C
中科院分区：
文献类型：
--
作者：
Ferreira VP;Pangburn MK;Cortés C
补体系统是先天免疫系统的重要组成部分，其参与病原体和改变的宿主细胞的消除，并且包含先天免疫系统和适应性免疫系统之间的重要联系。可溶性和膜结合补体调节剂保护细胞和组织免受补体介导的意外损伤。补体因子H是一种可溶性补体调节剂，对控制血液和细胞表面的旁路途径至关重要。自身细胞标记物（即聚阴离子）和C3 b/C3 d片段的正常识别对于因子H功能是必要的。由于突变和多态性，H因子对宿主细胞表面的识别不足与补体介导的组织损伤和疾病有关。另一方面，因子H对病原体和改变的自身细胞（即癌症）的不需要的识别被用作免疫逃避策略。这篇综述将集中在目前的知识与这些通用的识别特性的因子H。
The complement system is an essential component of the innate immune system that participates in elimination of pathogens and altered host cells and comprises an essential link between the innate and adaptive immune system. Soluble and membrane-bound complement regulators protect cells and tissues from unintended complement-mediated injury. Complement factor H is a soluble complement regulator essential for controlling the alternative pathway in blood and on cell surfaces. Normal recognition of self cell markers (i.e. polyanions) and C3b/C3d fragments is necessary for factor H function. Inadequate recognition of host cell surfaces by factor H due to mutations and polymorphisms have been associated with complement-mediated tissue damage and disease. On the other hand, unwanted recognition of pathogens and altered self cells (i.e. cancer) by factor H is used as an immune evasion strategy. This review will focus on the current knowledge related to these versatile recognition properties of factor H.
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DOI：
10.4049/jimmunol.0901826
发表时间：
2009-11-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Banda NK;Levitt B;Glogowska MJ;Thurman JM;Takahashi K;Stahl GL;Tomlinson S;Arend WP;Holers VM
通讯作者：
Holers VM
影响因子：
4.4
作者：
Ajona, Daniel;Hsu, Yi-Fan;Pio, Ruben
通讯作者：
Pio, Ruben
影响因子：
13.2
作者：
Davin, Jean-Claude;Gracchi, Valentina;Goodship, Tim
通讯作者：
Goodship, Tim
影响因子：
3.4
作者：
Chen, Mei;Forrester, John V.;Xu, Heping
通讯作者：
Xu, Heping
DOI：
10.1111/j.1651-2227.1981.tb05772.x
发表时间：
1981-01-01
期刊：
ACTA PAEDIATRICA SCANDINAVICA
影响因子：
--
作者：
ADINOLFI, M;DOBSON, NC;BRADWELL, AR
通讯作者：
BRADWELL, AR