Effect of the Age-Adjusted Charlson Comorbidity Index on the Survival of Esophageal Squamous Cell Carcinoma Patients after Radical Esophagectomy.
Effect of the Age-Adjusted Charlson Comorbidity Index on the Survival of Esophageal Squamous Cell Carcinoma Patients after Radical Esophagectomy.
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DOI：
10.3390/jcm11226737
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发表时间：
2022-11-14
影响因子：
3.9
通讯作者：
中科院分区：
文献类型：
--
作者：
本研究旨在探讨经年龄调整的Charlson合并症指数（ACCI）能否预测食管鳞状细胞癌（ESCC）患者的术后总生存期（OS）和癌症特异性生存期（CSS）。在2015年7月1日至2021年7月31日期间，在接受根治性食管切除术的原发性ESCC患者中进行了一项回顾性队列研究。共纳入352例患者，中位年龄为63.00（IQR（四分位距）56.00-68.00）。根据ACCI最佳临界值5分将患者分为低ACCI组（n = 300）和高ACCI组（n = 52）。慢性肺疾病（38.4%）是最常见的合并症。多因素考克斯回归分析结果显示，（HR = 1.63，95%CI：1.04-2.56），肿瘤大小（HR = 1.67，95%CI：1.05-2.66），pTNM（II vs. I，HR = 4.74，95%CI：1.82-12.32; III vs. I，HR = 6.08，95%CI：2.37-15.60）和术后化疗（HR = 0.60，95%CI：0.40-0.91）与OS显著相关。此外，ACCI、肿瘤大小、pTNM和术后化疗也与CSS显著相关。ACCI与术后化疗、pTNM分期和肿瘤大小之间的相互作用与OS和CSS有关。结论：ACCI可能是影响根治性食管切除术后患者长期预后的独立预后因素。
We aimed to investigate whether the age-adjusted Charlson comorbidity index (ACCI) can predict the postoperative overall survival (OS) and cancer-specific survival (CSS) of esophageal squamous cell carcinoma (ESCC) patients. Between 1 July 2015 and 31 July 2021, a retrospective cohort study was conducted among patients with primary ESCC who underwent radical esophagectomy. A total of 352 patients were included, with median age of 63.00 (IQR (interquartile range) 56.00–68.00). The patients were divided into low (n = 300) and high (n = 52) ACCI groups based on the optimal cut-off value of 5 points. Chronic pulmonary disease (38.4%) was the most common comorbidity. The results of the multivariate Cox regression showed that the ACCI (HR = 1.63, 95%CI: 1.04–2.56), tumor size (HR = 1.67, 95%CI: 1.05–2.66), pTNM (II vs. I, HR = 4.74, 95%CI: 1.82–12.32; III vs. I, HR = 6.08, 95%CI: 2.37–15.60), and postoperative chemotherapy (HR = 0.60, 95%CI: 0.40–0.91) were significantly associated with the OS. Furthermore, the ACCI, tumor size, pTNM, and postoperative chemotherapy were also significantly associated with the CSS. Interactions were identified between the ACCI and postoperative chemotherapy, pTNM stage, and tumor size in relation to the OS and CSS. In conclusion, the ACCI may be an independent prognostic factor affecting the long-term prognosis of patients after radical esophagectomy.
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影响因子：
4.7
作者：
Robbins, Jared R.;Gayar, Omar H.;Elshaikh, Mohamed A.
通讯作者：
Elshaikh, Mohamed A.
影响因子：
3.8
作者：
Dias-Santos, Daniela;Ferrone, Cristina R.;Fernandez-del Castillo, Carlos
通讯作者：
Fernandez-del Castillo, Carlos
影响因子：
1.6
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通讯作者：
Pu H
影响因子：
5.5
作者：
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通讯作者：
Pan X
影响因子：
3
作者：
Bannay, Aurelie;Chaignot, Christophe;Alla, Francois
通讯作者：
Alla, Francois