Interactions between oxygen homeostasis, food availability, and hydrogen sulfide signaling.
Interactions between oxygen homeostasis, food availability, and hydrogen sulfide signaling.
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DOI：
10.3389/fgene.2012.00257
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发表时间：
2012
影响因子：
3.7
通讯作者：
Miller DL
中科院分区：
文献类型：
--
作者：
Iranon NN;Miller DL
感知和应对压力环境的能力对于维持机体的动态平衡至关重要。人们早就认识到，在不断变化的条件下提高存活率的应激反应因素也会影响寿命。在这篇综述中，我们讨论了动物对低氧(低氧)反应的不同策略，以维持O2动态平衡，并考虑低氧反应、营养状态和H_2S信号之间的相互作用。O2是几乎所有后生动物必不可少的环境营养物质，因为它在发育和细胞新陈代谢中发挥着重要作用。然而，对低氧的生理反应(S)在很大程度上取决于可利用的氧气量。动物必须感觉到氧气供应的减少，才能协调基本的代谢和信号通路。参与对低氧反应的因素也参与了对其他关键环境信号的反应，特别是食物的供应，这并不令人惊讶。最近对哺乳动物的研究也表明，小的气体信号分子硫化氢(H2S)可以保护细胞免受缺氧损伤和死亡。这些结果表明，H_2S信号也与低氧反应整合(S)。许多介导低氧、食物匮乏和硫化氢信号影响的信号通路也参与了寿命的控制。因此，了解这些途径是如何协调的，就有可能揭示有助于动物长寿的新的细胞和组织内环境平衡机制。
The ability to sense and respond to stressful conditions is essential to maintain organismal homeostasis. It has long been recognized that stress response factors that improve survival in changing conditions can also influence longevity. In this review, we discuss different strategies used by animals in response to decreased O2 (hypoxia) to maintain O2 homeostasis, and consider interactions between hypoxia responses, nutritional status, and H2S signaling. O2 is an essential environmental nutrient for almost all metazoans as it plays a fundamental role in development and cellular metabolism. However, the physiological response(s) to hypoxia depend greatly on the amount of O2 available. Animals must sense declining O2 availability to coordinate fundamental metabolic and signaling pathways. It is not surprising that factors involved in the response to hypoxia are also involved in responding to other key environmental signals, particularly food availability. Recent studies in mammals have also shown that the small gaseous signaling molecule hydrogen sulfide (H2S) protects against cellular damage and death in hypoxia. These results suggest that H2S signaling also integrates with hypoxia response(s). Many of the signaling pathways that mediate the effects of hypoxia, food deprivation, and H2S signaling have also been implicated in the control of lifespan. Understanding how these pathways are coordinated therefore has the potential to reveal new cellular and organismal homeostatic mechanisms that contribute to longevity assurance in animals.
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影响因子：
20.1
作者：
Calvert JW;Jha S;Gundewar S;Elrod JW;Ramachandran A;Pattillo CB;Kevil CG;Lefer DJ
通讯作者：
Lefer DJ
影响因子：
37.8
作者：
Calvert JW;Elston M;Nicholson CK;Gundewar S;Jha S;Elrod JW;Ramachandran A;Lefer DJ
通讯作者：
Lefer DJ
影响因子：
5.4
作者：
Danovaro R;Dell'Anno A;Pusceddu A;Gambi C;Heiner I;Kristensen RM
通讯作者：
Kristensen RM
DOI：
10.1126/science.1166175
发表时间：
2009-01-30
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Anderson LL;Mao X;Scott BA;Crowder CM
通讯作者：
Crowder CM
影响因子：
16
作者：
Banko, Max R.;Allen, Jasmina J.;Schaffer, Bethany E.;Wilker, Erik W.;Tsou, Peiling;White, Jamie L.;Villen, Judit;Wang, Beatrice;Kim, Sara R.;Sakamoto, Kei;Gygi, Steven P.;Cantley, Lewis C.;Yaffe, Michael B.;Shokat, Kevan M.;Brunet, Anne
通讯作者：
Brunet, Anne