Immunogenicity of COVID-19 vaccines and their effect on HIV reservoir in older people with HIV.
Immunogenicity of COVID-19 vaccines and their effect on HIV reservoir in older people with HIV.
复制标题
DOI：
10.1016/j.isci.2023.107915
复制
发表时间：
2023-10-20
期刊：
影响因子：
5.8
通讯作者：
Ostrowski, Mario
中科院分区：
文献类型：
--
作者：
Matveev, Vitaliy A.;Mihelic, Erik Z.;Benko, Erika;Budylowski, Patrick;Grocott, Sebastian;Lee, Terry;Korosec, Chapin S.;Colwill, Karen;Stephenson, Henry;Law, Ryan;Ward, Lesley A.;Sheikh-Mohamed, Salma;Mailhot, Genevieve;Delgado-Brand, Melanie;Pasculescu, Adrian;Wang, Jenny H.;Qi, Freda;Tursun, Tulunay;Kardava, Lela;Chau, Serena;Samaan, Philip;Imran, Annam;Copertino Jr, Dennis C.;Chao, Gary;Choi, Yoojin;Reinhard, Robert J.;Kaul, Rupert;Heffernan, Jane M.;Jones, R. Brad;Chun, Tae-Wook;Moir, Susan;Singer, Joel;Gommerman, Jennifer;Gingras, Anne-Claude;Kovacs, Colin;Ostrowski, Mario
老年人和艾滋病毒感染者（PWH）被优先接种COVID-19疫苗，但这些疫苗的免疫原性及其对艾滋病毒宿主的影响的全面研究尚不可用。我们对68名55岁及以上的PWH和23名HIV阴性参与者进行的研究显示，从基线到第48周，血清和唾液中的抗尖峰IgG反应同样强烈，而PWH唾液伊加反应较低。PWH在两次疫苗接种后减少了活病毒中和反应，这是在加强后“拯救”的。在CD 4 + T细胞计数正常的PWH中，刺突特异性T细胞免疫增强，表明Th 1印迹。可检测到的HIV病毒血症的频率在接种疫苗后增加，但疫苗并不影响大多数PWH中HIV储库的大小，除了那些低水平的病毒血症。因此，年长的威尔斯亲王医院需要接种三剂COVID-19疫苗以获得最大保护，而患有未抑制病毒血症的个人应监测艾滋病毒宿主的不良反应。第三次SARS-CoV-2疫苗剂量挽救了老年PWH中减少的nAb应答接种疫苗后PWH唾液中减少的尖峰伊加应答来自HIV的Th 1印记增强了CD 4计数正常的PWH中的尖峰T细胞免疫HIV储库在接种疫苗后没有生长，但在病毒血症未受抑制的PWH中除外免疫学;病毒学
Older individuals and people with HIV (PWH) were prioritized for COVID-19 vaccination, yet comprehensive studies of the immunogenicity of these vaccines and their effects on HIV reservoirs are not available. Our study on 68 PWH and 23 HIV-negative participants aged 55 and older post-three vaccine doses showed equally strong anti-spike IgG responses in serum and saliva through week 48 from baseline, while PWH salivary IgA responses were low. PWH had diminished live-virus neutralization responses after two vaccine doses, which were ‘rescued’ post-booster. Spike-specific T cell immunity was enhanced in PWH with normal CD4+ T cell count, suggesting Th1 imprinting. The frequency of detectable HIV viremia increased post-vaccination, but vaccines did not affect the size of the HIV reservoir in most PWH, except those with low-level viremia. Thus, older PWH require three doses of COVID-19 vaccine for maximum protection, while individuals with unsuppressed viremia should be monitored for adverse reactions from HIV reservoirs. Third SARS-CoV-2 vaccine dose rescued diminished nAb responses in older PWH PWH had diminished spike IgA responses in saliva after vaccination Th1 imprinting from HIV enhances spike T cell immunity in PWH with normal CD4 count HIV reservoir did not grow post-vaccine, except in PWH with unsuppressed viremia Immunology; Virology
登录
查看更多内容
DOI：
10.3390/v15020575
发表时间：
2023-02-19
期刊：
Viruses
影响因子：
--
作者：
Alexandrova Y;Yero A;Mboumba Bouassa RS;Comeau E;Samarani S;Brumme ZL;Hull M;Crawley AM;Langlois MA;Angel JB;Cooper CL;Needham J;Lee T;Singer J;Anis AH;Costiniuk CT;Jenabian MA
通讯作者：
Jenabian MA
DOI：
10.1056/nejmoa2105290
发表时间：
2021-12-16
期刊：
The New England journal of medicine
影响因子：
--
作者：
Falsey AR;Sobieszczyk ME;Hirsch I;Sproule S;Robb ML;Corey L;Neuzil KM;Hahn W;Hunt J;Mulligan MJ;McEvoy C;DeJesus E;Hassman M;Little SJ;Pahud BA;Durbin A;Pickrell P;Daar ES;Bush L;Solis J;Carr QO;Oyedele T;Buchbinder S;Cowden J;Vargas SL;Guerreros Benavides A;Call R;Keefer MC;Kirkpatrick BD;Pullman J;Tong T;Brewinski Isaacs M;Benkeser D;Janes HE;Nason MC;Green JA;Kelly EJ;Maaske J;Mueller N;Shoemaker K;Takas T;Marshall RP;Pangalos MN;Villafana T;Gonzalez-Lopez A;AstraZeneca AZD1222 Clinical Study Group
通讯作者：
AstraZeneca AZD1222 Clinical Study Group
影响因子：
8.8
作者：
Grupper, Ayelet;Rabinowich, Liane;Katchman, Helena
通讯作者：
Katchman, Helena
影响因子：
11.8
作者：
Dandachi, Dima;Geiger, Grant;Chow, Jeremy
通讯作者：
Chow, Jeremy
影响因子：
8
作者：
Abe, Kento T.;Li, Zhijie;Gingras, Anne-Claude
通讯作者：
Gingras, Anne-Claude