Spermatogenesis-defective (spe) mutants of the nematode Caenorhabditis elegans provide clues to solve the puzzle of male germline functions during reproduction.
Spermatogenesis-defective (spe) mutants of the nematode Caenorhabditis elegans provide clues to solve the puzzle of male germline functions during reproduction.
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DOI：
10.1002/dvdy.22271
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发表时间：
2010-05
影响因子：
2.5
通讯作者：
L'Hernault, Steven W.
中科院分区：
文献类型：
--
作者：
Nishimura, Hitoshi;L'Hernault, Steven W.
关键词：
在大多数物种中，每种性别都在配子发生过程中从其种系产生配子，通常是精子或卵母细胞。精子和卵母细胞随后在受精过程中融合在一起，创造下一代。本文综述了秀丽隐杆线虫精子发生和精子在受精过程中的作用，在那里很容易获得合适的突变体。到目前为止，有186个C.已分离出秀丽线虫雄性生殖系功能，并且这些突变中的许多是约60个精子发生缺陷（SPE）基因之一的等位基因。许多克隆的spe基因在雄性生殖细胞中特异性表达，它们在精子发生（精子细胞产生）、精子发生（精子细胞活化成精子）和/或受精过程中发挥作用。此外，一些spe基因是哺乳动物基因的直系同源物，这表明C。线虫和哺乳动物雄性生殖系在分子水平上可能有共同的途径。
In most species, each sex produces gametes, usually either sperm or oocytes, from its germline during gametogenesis. The sperm and oocyte subsequently fuse together during fertilization to create the next generation. This review focuses on spermatogenesis and the roles of sperm during fertilization in the nematode Caenorhabditis elegans, where suitable mutants are readily obtained. So far 186 mutants defective in the C. elegans male germline functions have been isolated, and many of these mutations are alleles for one of the ~60 spermatogenesis-defective (spe) genes. Many cloned spe genes are expressed specifically in the male germline, where they play roles during spermatogenesis (spermatid production), spermiogenesis (spermatid activation into spermatozoa), and/or fertilization. Moreover, several spe genes are orthologs of mammalian genes, suggesting that the reproductive processes of the C. elegans and the mammalian male germlines might share common pathways at the molecular level.
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