Marginal zone B cells regulate antigen capture by marginal zone macrophages.
Marginal zone B cells regulate antigen capture by marginal zone macrophages.
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DOI：
10.4049/jimmunol.1002106
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发表时间：
2011-02-15
期刊：
影响因子：
--
通讯作者：
Carter RH
中科院分区：
文献类型：
--
作者：
You Y;Myers RC;Freeberg L;Foote J;Kearney JF;Justement LB;Carter RH
小鼠脾脏的边缘区（MZ）含有表达捕获病原体的受体的巨噬细胞，包括具有胶原结构的清道夫受体巨噬细胞受体和C型凝集素特异性细胞内粘附分子抓取非整联蛋白受体1（SIGN-R1）。我们先前报道了SIGN-R1的表达在CD 19缺陷小鼠中降低。在这项研究中，我们证明，SIGN-R1表达的巨噬细胞受体与胶原结构（MARCO）+巨噬细胞的一个子集。当MZ B细胞由于遗传发育缺陷或B细胞短暂迁移出MZ而缺失时，该亚群减少。当B细胞返回MZ时，SIGN-R1表达巨噬细胞的恢复延迟。在此期间，巨噬细胞需要SIGN-R1的Ficoll捕获不仅被巨噬细胞而且被B细胞保持缺陷。因此，MZ B细胞调节巨噬细胞上对捕获Ag重要的分子的表达，而这又是B细胞捕获Ag所需的。
The marginal zone (MZ) of the mouse spleen contains macrophages that express receptors that trap pathogens, including the scavenger receptor macrophage receptor with a collagenous structure and the C-type lectin specific intracellular adhesion molecule-grabbing nonintegrin receptor 1 (SIGN-R1). We previously reported that expression of SIGN-R1 was decreased in CD19-deficient mice. In this study, we demonstrate that SIGN-R1 is expressed on a subset of macrophage receptor with a collagenous structure (MARCO)+ macrophages. This subset is diminished when MZ B cells are absent due to either genetic developmental defects or following transient migration of B cells out of the MZ. When B cells return to the MZ, there is a delay in recovery of SIGN-R1–expressing macrophages. During this period, capture of Ficoll, which for the macrophages requires SIGN-R1, remains defective not only by the macrophages, but also by the B cells. Thus, MZ B cells regulate expression of molecules on macrophages that are important for trapping Ag, which, in turn, is required for Ag capture by the B cells.
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影响因子：
64.5
作者：
Kang, YS;Do, YY;Park, CG
通讯作者：
Park, CG
影响因子：
64.8
作者：
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通讯作者：
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DOI：
10.1073/pnas.0307124101
发表时间：
2004-01-06
影响因子：
11.1
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通讯作者：
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影响因子：
20.3
作者：
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30.5
作者：
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