The impact of an 8-year mass drug administration programme on prevalence, intensity and co-infections of soil-transmitted helminthiases in Burundi.
The impact of an 8-year mass drug administration programme on prevalence, intensity and co-infections of soil-transmitted helminthiases in Burundi.
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DOI：
10.1186/s13071-016-1794-9
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发表时间：
2016-09-22
影响因子：
3.2
通讯作者：
Magalhaes RJ
中科院分区：
文献类型：
--
作者：
Ortu G;Assoum M;Wittmann U;Knowles S;Clements M;Ndayishimiye O;Basáñez MG;Lau C;Clements A;Fenwick A;Magalhaes RJ
土壤传播的蠕虫感染是世界上最普遍的感染之一。大规模给药规划已成为流行国家实现消除的最常用的国家干预措施。本文旨在描述从2007年到2014年，一项为期8年的MDA规划对布隆迪STH的流行、感染强度和合并感染的影响，并批判性地评估该国消除STH的轨迹。年度STH寄生虫学调查（具体而言，2007年至2011年的“试点研究”，2008年至2011年的“推广研究”，以及2014年的“全国重新评估”；n = 27,658名儿童）显示，在这两项研究中，从基线到2011年，任何STH（“集中STH”）的感染率都有显著下降，在试点研究中从32%降至16%，在推广研究中从35%降至16%。根据WHO的分类，大多数STH感染为低强度感染。2014年的全国重新评估显示，在这两项研究中，集中的STH患病率仍明显低于2007年的患病率，但在此期间STH患病率没有进一步下降。空间依赖性分析表明，毛滴虫和蛔虫的流行趋势呈聚类趋势，而钩虫的流行趋势呈空间依赖性。在整个方案实施过程中，类蚓蛔虫和毛线虫的空间依赖性有所波动。2010年，类蛔虫的空间依赖趋势较为明显。感染强度和重感染的空间聚类分析表明，所有寄生虫的感染强度随时间变化。仅2008年在类蚓蛔虫中有明显的高强度，在随后年份和其他寄生虫中未出现。这些结果表明，持续每年的丙二醛可显著降低学龄儿童的STH感染率，但无法完全消除。此外，自2008年以来，流行率显著下降的同时，所有站点的感染指标空间聚类也有所下降。空间依赖性分析结果的不一致性突出表明，MDA规划可以中断STH寄生虫的正常传播动态。本文的在线版本（doi:10.1186/s13071-016-1794-9）包含补充材料，可供授权用户使用。
Soil-transmitted helminth (STH) infections are amongst the most prevalent infections in the world. Mass drug administration (MDA) programmes have become the most commonly used national interventions for endemic countries to achieve elimination. This paper aims to describe the effect of an 8-year MDA programme on the prevalence, intensity of infection and co-infection of STH in Burundi from 2007 to 2014 and critically appraise the trajectory towards STH elimination in the country. Annual STH parasitological surveys (specifically, a “pilot study” from 2007 to 2011, an “extension study” from 2008 to 2011, and a “national reassessment” in 2014; n = 27,658 children), showed a significant drop in prevalence of infection with any STH (“pooled STH”) between baseline and 2011 in both studies, falling from 32 to 16 % in the pilot study, and from 35 to 16 % in the extension study. Most STH infections were of low intensity according to WHO classification. The national reassessment in 2014 showed that prevalence of pooled STH remained significantly below the prevalence in 2007 in both studies but there was no further decrease in STH prevalence from 2011 levels during this time. Spatial dependence analysis showed that prevalence of Trichuris trichiura and Ascaris lumbricoides had a tendency to cluster over the years, whilst only trends in spatial dependence were evident for hookworm infections. Spatial dependence fluctuated over the course of the programme for Ascaris lumbricoides and Trichuris trichiura. However, spatial trends in spatial dependence were evident in 2010 for Ascaris lumbricoides. Analysis of spatial clustering of intensity of infection and heavy infections revealed that the intensity changed over time for all parasites. Heavy intensity was only evident in Ascaris lumbricoides for 2008 and did not appear in proceeding years and other parasites. These results demonstrate that sustained annual MDA significantly reduced the prevalence of STH infection in school-age children but was unable to achieve elimination. Additionally, significant decline in prevalence was accompanied by a drop in spatial clustering of infection indicators across all sites from 2008. The lack of consistency in the results of the spatial dependence analysis highlights that MDA programmes can interrupt the normal transmission dynamics of STH parasites. The online version of this article (doi:10.1186/s13071-016-1794-9) contains supplementary material, which is available to authorized users.
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DOI：
10.1073/pnas.1106784108
发表时间：
2011-12-13
影响因子：
11.1
作者：
Magalhaes, Ricardo J. Soares;Barnett, Adrian G.;Clements, Archie C. A.
通讯作者：
Clements, Archie C. A.
影响因子：
3.8
作者：
Soares Magalhães RJ;Biritwum NK;Gyapong JO;Brooker S;Zhang Y;Blair L;Fenwick A;Clements AC
通讯作者：
Clements AC
影响因子：
1.6
作者：
Mascarini-Serra, Luciene
通讯作者：
Mascarini-Serra, Luciene
全球流行病学，生态学和控制土壤传播的蠕虫感染。
影响因子：
--
作者：
Brooker, S.;Clements, A. C. A.;Bundy, D. A. P.
通讯作者：
Bundy, D. A. P.
影响因子：
11.1
作者：
Kabatereine, Narcis B;Brooker, Simon;Koukounari, Artemis;Kazibwe, Francis;Tukahebwa, Edridah M;Fleming, Fiona M;Zhang, Yaobi;Webster, Joanne P;Stothard, J Russell;Fenwick, Alan
通讯作者：
Fenwick, Alan