Polygenic risk score for Parkinson's disease and olfaction among middle-aged to older women.
Polygenic risk score for Parkinson's disease and olfaction among middle-aged to older women.
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中老年女性帕金森病和嗅觉的多基因风险评分。
DOI：
10.1016/j.parkreldis.2023.105815
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发表时间：
2023
影响因子：
4.1
通讯作者：
Chen,Honglei
中科院分区：
文献类型：
--
作者：
Cao,Zichun;Hernandez,DenaG;Li,Chenxi;Berghausen,Joos;Luo,Zhehui;Iwaki,Hirotaka;D'Aloisio,AimeeA;Huang,Xuemei;Pinto,JayantM;Sandler,DaleP;Singleton,AndrewB;Chen,Honglei
嗅觉障碍和帕金森病（PD）可能有共同的遗传和环境危险因素。本研究调查了PD多基因风险评分（PRS）与嗅觉的相关性，以及这些相关性是否被PM2.5，NO2或吸烟的环境暴露所改变。MethodsThis分析包括来自姐妹研究的3358名女性（年龄50-80岁），这些女性的遗传数据和2018-2019年进行的简明身份识别测试（B-SIT）的结果。使用90个单核苷酸多态性计算PD PRS。嗅觉障碍定义为不同的B-SIT截止值，PD诊断通过专家评审裁定。我们报告的优势比（OR）和95%的置信区间（CI）从多变量logistic regulation.ResultsAs预期，PD PRS是密切相关的几率有PD（OR最高与最低四分位数= 3.79（1.64，8.73））。最高的PRS四分位数也与嗅觉障碍相关，OR范围从B-SIT临界值9的1.24（0.98，1.56）到临界值6的1.42（1.04，1.92）。对于单个B-SIT项目，最高PRS四分位数通常与正确识别气味剂的几率较低相关，尽管仅对菠萝（0.72（0.56，0.94））、肥皂（0.76（0.58，0.99））和玫瑰（0.70（0.54，0.92））具有统计学显著性。PD PRS与嗅觉障碍的关联没有修改空气中的环境暴露或smoking.ConclusionThese初步数据表明，高PD遗传易感性与嗅觉障碍在中年和老年妇女。
IntroductionOlfactory impairment and Parkinson's disease (PD) may share common genetic and environmental risk factors. This study investigates the association of a PD polygenic risk score (PRS) with olfaction, and whether the associations are modified by environmental exposures of PM2.5, NO2, or smoking.MethodsThis analysis included 3358 women (aged 50–80) from the Sister Study with genetic data and results from the Brief Smell Identification Test (B-SIT) administered in 2018–2019. PD PRS was calculated using 90 single nucleotide polymorphisms. Olfactory impairment was defined with different B-SIT cutoffs, and PD diagnosis was adjudicated via expert review. We report odds ratios (ORs) and 95% confidence intervals (CIs) from multivariable logistic regression.ResultsAs expected, PD PRS was strongly associated with the odds of having PD (OR highest vs. lowest quartile = 3.79 (1.64, 8.73)). The highest PRS quartile was also associated with olfactory impairment, with OR ranging from 1.24 (0.98, 1.56) for a B-SIT cutoff of 9 to 1.42 (1.04, 1.92) for a cutoff of 6. For individual B-SIT items, the highest PRS quartile was generally associated with lower odds of correctly identifying the odorant, albeit only statistically significant for pineapple (0.72 (0.56, 0.94), soap (0.76 (0.58, 0.99)) and rose (0.70 (0.54, 0.92)). The association of PD PRS with olfactory impairment was not modified by airborne environmental exposures or smoking.ConclusionThese preliminary data suggest that high PD genetic susceptibility is associated with olfactory impairment in middle-aged and older women.
糟糕的空气和帕金森病——雾气可能会消散。
影响因子：
29
作者：
E. Dorsey;M. Okun;C. Tanner
通讯作者：
C. Tanner
影响因子：
3.5
作者：
Koch S;Laabs BH;Kasten M;Vollstedt EJ;Becktepe J;Brüggemann N;Franke A;Krämer UM;Kuhlenbäumer G;Lieb W;Mollenhauer B;Neis M;Trenkwalder C;Schäffer E;Usnich T;Wittig M;Klein C;König IR;Lohmann K;Krawczak M;Caliebe A
通讯作者：
Caliebe A
影响因子：
14
作者：
Tanner, Caroline M.;Goldman, Samuel M.;Grate, Stephen J.
通讯作者：
Grate, Stephen J.