EMX2 is Downregulated in Endometrial Cancer and Correlated With Tumor Progression
EMX2 is Downregulated in Endometrial Cancer and Correlated With Tumor Progression
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EMX2 在子宫内膜癌中下调并与肿瘤进展相关
DOI：
10.1097/pgp.0b013e31825d8049
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发表时间：
2013-03
影响因子：
2.4
通讯作者：
X Wan
中科院分区：
文献类型：
--
作者：
H Qiu;Q Yan;X Luo;H Zhang;W Bao;X Wan
EMX2(果蝇空气孔基因2的人类同源基因)是一种候选的肿瘤抑制基因。然而，它在子宫内膜癌中的作用仍不清楚。在本研究中，我们研究了EMX2在不同亚型子宫内膜癌中的表达及其与临床病理特征的关系。应用免疫组织化学方法检测122例子宫内膜癌和25例正常子宫内膜组织中EMX2蛋白的表达。用统计软件分析EMX2的表达与患者临床病理特征的关系。与正常子宫内膜相比，子宫内膜癌组织中EMX2的表达显著下调(P<；0.001)。EMX2表达降低与肿瘤分期(P=0.023)、分级(P=0.016)和肌层侵犯深度(P=0.016)有关，而与年龄、病理亚型、淋巴结转移、淋巴管腔侵犯或ER/PR/P53状态无关。EMX2的表达下调与肿瘤的进展有关，可能是子宫内膜癌发生发展的关键因素，为临床治疗提供了新的靶点和预测预后的潜在指标。
EMX2 (the human homologue of Drosophila empty spiracles gene 2) is a candidate tumor suppressor. However, its roles in endometrial cancer are still unknown. In this study, we evaluated EMX2 expression in different subtypes of endometrial cancer and its relationships with clinicopathologic characteristics. By immunohistochemical staining, we investigated the level of EMX2 protein in 122 endometrial cancer and 25 normal endometrium tissues. Correlations between EMX2 expression and clinicopathologic features of patients were analyzed using a statistical software. Compared with the normal endometrium, the expression of EMX2 was significantly downregulated in endometrial cancer tissues (P<0.001). Reduced EMX2 expression was correlated with the tumor stage (P=0.023), grade (P=0.016), and the depth of myometrial invasion (P=0.04), but not with age, pathologic subtype, lymph node metastasis, lymph vascular space invasion, or ER/PR/p53 status. Downregulation of EMX2 was associated with tumor progression and may be a critical factor in the carcinogenesis and progression of endometrial cancer, which provided a novel therapeutic target and a potential marker for prognostic prediction.
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影响因子：
3.6
作者：
Okamoto J;Kratz JR;Hirata T;Mikami I;Raz D;Segal M;Chen Z;Zhou HM;Pham P;Li H;Yagui-Beltran A;Ray MR;Koizumi K;Shimizu K;Jablons D;He B
通讯作者：
He B
DOI：
10.1891/9780826121646.0002
发表时间：
2018-09
期刊：
Cancer Rehabilitation
影响因子：
--
作者：
K. Miller;R. Siegel;R. Khan;A. Jemal
通讯作者：
K. Miller;R. Siegel;R. Khan;A. Jemal
影响因子：
11.2
作者：
Lacey JV Jr;Mutter GL;Ronnett BM;Ioffe OB;Duggan MA;Rush BB;Glass AG;Richesson DA;Chatterjee N;Langholz B;Sherman ME
通讯作者：
Sherman ME
EMX2 在表观遗传上被沉默并抑制人类肺癌的生长
影响因子：
8
作者：
J. Okamoto;T. Hirata;Z. Chen;H.M. Zhou;I. Mikami;H. Li;A. Yagui;M. Johansson;L. Coussens;G. Clément;Y. Shi;F. Zhang;K. Koizumi;K. Shimizu;D. Jablons;B. He
通讯作者：
B. He
DOI：
10.1007/174_2017_91
发表时间：
2017
期刊：
--
影响因子：
--
作者：
Mariana Horta;T. Cunha
通讯作者：
Mariana Horta;T. Cunha