Effects of Hypoxia in Developing Swine
Effects of Hypoxia in Developing Swine
复制标题
缺氧对发育中猪的影响
DOI：
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复制
发表时间：
1990
期刊：
影响因子：
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通讯作者：
M. Gandhi
中科院分区：
文献类型：
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作者：
P. M. Gootman;N. Gootman;B. Buckley;B. J. Peterson;A. Steele;A. Sica;M. Gandhi
缺氧是一种并发症，经常发生在人类婴儿谁经历了围产期的压力。虽然心血管（CV）对缺氧的反应在胎儿和成人都有很好的记录，但关于出生后局部循环对缺氧的反应的成熟信息有限，更不用说交感神经节律发生系统（SRGS），如通过记录自发传出交感神经（SAMP）活动所监测的。另一方面，缺氧对发育中的呼吸节律发生器（RRG）的影响在许多物种中已有很好的记录（参见Gootman等人，1989; Steele，1986）。在我们以前的研究中，成熟相关的反应，以其他压力，即，出血和高碳酸血症（Buckley等人，1984; Gootman等人，1985年; Reddy等人，1974年）。这种动物模型在出生时比羔羊和豚鼠不成熟，而在出生时比小狗、大鼠和小猫更成熟（N.M. Buckley，1983，1986; Gootman，1983）。本文总结了两种不同程度的缺氧对猪从出生到2月龄的四种不同区域循环以及传出性SYMP和膈神经活动的影响。
Hypoxia is a complication which frequently occurs in human infants who have experienced perinatal stress. Although cardiovascular (CV) responses to hypoxia are well documented in both the fetus and adult, there is limited information about the postnatal maturation of regional circulatory responses to hypoxia, still less on the sympathetic rhythm generating systems (SRGS), as monitored by recordings of spontaneous efferent sympathetic (SAMP) activity. On the other hand, the effects of hypoxia on the developing respiratory rhythm generator (RRG) have been well documented in many species (cf. Gootman et al., 1989; Steele, 1986). In our previous studies, maturation- related responses to other stresses, i.e., hemorrhage and hypercapnia, were observed in swine (Buckley et al., 1984; Gootman et al., 1985; Reddy et al., 1974). This animal model is less mature at birth than lambs and guinea pigs, and more mature at birth than puppies, rats, and kittens (N.M. Buckley, 1983, 1986; Gootman, 1983). This paper summarizes our studies on the effects of two degrees of hypoxia on four different regional circulations and on efferent SYMP and phrenic activity in swine from birth to 2 months of age.
DOI：
10.1152/ajpregu.1984.247.4.r626
发表时间：
1984
期刊：
The American journal of physiology
影响因子：
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作者：
Buckley,BJ;Gootman,N;Nagelberg,JS;Griswold,PG;Gootman,PM
通讯作者：
Gootman,PM