Linear IgA Bullous Dermatosis Preceding the Diagnosis of Primary Sclerosing Cholangitis and Ulcerative Colitis: A Case Report.
Linear IgA Bullous Dermatosis Preceding the Diagnosis of Primary Sclerosing Cholangitis and Ulcerative Colitis: A Case Report.
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原发性硬化性胆管炎和溃疡性结肠炎诊断前的线性 IgA 大疱性皮肤病：病例报告。
DOI：
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发表时间：
2019
影响因子：
1.1
通讯作者：
J. Jaroslaw
中科院分区：
文献类型：
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作者：
V. Humphrey;J. J. Lee;Teerawit Supakorndej;S. Malik;Arthur C. Huen;J. Jaroslaw
线性伊加大疱性皮肤病（LABD）是一种罕见的自身免疫性起泡疾病，见于儿科和成人人群，通常与药物治疗、感染或潜在的胃肠道、肝胆或自身免疫性疾病有关。在这项研究中，我们描述的情况下，一个23岁的白色男子的介绍和诊断LABD最终导致发现潜在的原发性硬化性胆管炎（PSC）和溃疡性结肠炎（UC）。他的皮炎用局部类固醇和氨苯砜解决，他正在接受UC和PSC的全身治疗。这一例外病例进一步证实了LABD与UC之间的相关性，加强了与PSC之间的相关性，并强调了提醒临床医生在诊断LABD时，除了全面的用药史外，还应考虑进行系统性检查的重要性。
Linear IgA bullous dermatosis (LABD) is a rare autoimmune blistering disorder seen in the pediatric and adult populations that is often linked to a medication, infection, or underlying gastrointestinal, hepatobiliary, or autoimmune disease. In this study, we describe the case of a 23-year-old white man whose presentation and diagnosis of LABD ultimately led to the discovery of underlying primary sclerosing cholangitis (PSC) and ulcerative colitis (UC). His dermatitis resolved with topical steroids and dapsone, and he is undergoing systemic treatment for his UC and PSC. This exceptional case further validates the association between LABD with UC, strengthens that with PSC, and underscores the importance of alerting clinicians to consider conducting a systemic workup in addition to thorough medication history on making the diagnosis of LABD.
识别 LABD97 的 IgA 抗体主要是 IgA1 亚类。
影响因子：
3.6
作者：
Egan,CA;Martineau,MR;Taylor,TB;Meyer,LJ;Petersen,MJ;Zone,JJ
通讯作者：
Zone,JJ