Both L3T4+ and Lyt-2+ helper T cells initiate cytotoxic T lymphocyte responses against allogenic major histocompatibility antigens but not against trinitrophenyl-modified self
Both L3T4+ and Lyt-2+ helper T cells initiate cytotoxic T lymphocyte responses against allogenic major histocompatibility antigens but not against trinitrophenyl-modified self
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L3T4 和 Lyt-2 辅助 T 细胞均启动针对同种异体主要组织相容性抗原的细胞毒性 T 淋巴细胞应答，但不针对三硝基苯基修饰的自身抗原
DOI：
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发表时间：
1985
影响因子：
15.3
通讯作者：
A. Singer
中科院分区：
文献类型：
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作者：
T. Mizuochi;H. Golding;A. Rosenberg;L. Glimcher;T. Malek;A. Singer
本研究描述了T辅助细胞（Th）对同种异体和三硝基苯（TNP）修饰的自身I类主要组织相容性（MHC）决定因子启动原代细胞毒性T淋巴细胞（CTL）反应的特性。我们发现两种不同的Th细胞亚群参与异体特异性CTL反应：(a) L3T4+，Lyt-2- II类受限的Th细胞群，以及(b) L3T4-，Lyt-2+ I类受限的Th细胞群。这两种T细胞亚群通过与同种异体CTL前体的协同作用，在同种异体CTL反应中作为辅助细胞发挥作用。因此，初级I类异体特异性CTL反应不仅涉及L3T4+ Th细胞，还涉及Lyt-2+ Th细胞。L3T4+和Lyt-2+ Th细胞群在异位特异性CTL反应中发挥的必要功能之一是分泌白细胞介素2。最后，尽管抗allo和抗tnp - ctl反应有许多相似之处，但发现抗tnp - ctl反应仅由L3T4+ Th细胞介导，而不是由Lyt-2+ Th细胞介导。因此，Lyt-2+ Th细胞似乎是主要参与mhc特异性免疫反应的辅助细胞群。
This study characterizes the T helper (Th) cells that initiate primary cytotoxic T lymphocyte (CTL) responses against allogeneic and trinitrophenyl (TNP)-modified self class I major histocompatibility (MHC) determinants. We show that two distinct Th cell subsets participate in allospecific CTL responses: (a) an L3T4+,Lyt-2- class II- restricted Th cell population, and (b) an L3T4-,Lyt-2+ class I- restricted Th cell population. Both of these T cell subpopulations were shown to function in allospecific CTL responses as helper cells by their ability to show synergy with allospecific CTL precursors. Thus, primary class I allospecific CTL responses represent an immune response involving not only L3T4+ Th cells, but Lyt-2+ Th cells as well. One of the necessary functions performed by both L3T4+ and Lyt-2+ Th cell populations in allospecific CTL responses was found to be the secretion of interleukin 2. Finally, despite the many similarities between anti- allo- and anti-TNP-CTL responses, anti-TNP-CTL responses were found to be mediated by only L3T4+ Th cells, not by Lyt-2+ Th cells. Consequently, Lyt-2+ Th cells appear to be a helper cell population that is primarily involved in MHC-specific immune responses.
同基因 Ia 辅助细胞在同种异体特异性 CTL 反应产生中的作用。
DOI：
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发表时间：
1982
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Weinberger,O;Germain,RN;Springer,T;Burakoff,SJ
通讯作者：
Burakoff,SJ
对次要组织相容性抗原具有特异性的非辅助细胞依赖性溶细胞 T 淋巴细胞。
DOI：
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发表时间：
1983
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Roopenian,DC;Widmer,MB;Orosz,CG;Bach,FH
通讯作者：
Bach,FH
产生溶细胞性 T 淋巴细胞反应中的细胞相互作用：Ia 阳性脾贴壁细胞在 H-2 抗原呈递中的作用。
DOI：
10.1073/pnas.77.10.6091
发表时间：
1980
影响因子：
11.1
作者：
Weinberger,O;Herrmann,SH;Mescher,MF;Benacerraf,B;Burakoff,SJ
通讯作者：
Burakoff,SJ